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Envelope C2-V3-C3-specific antibodies from HIV-1 infected patients from Angola correlate with neutralization activity in plasma

2015-03-22Conference object Open access
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dc.contributor.authorCalado, R.
dc.contributor.authorDuarte, J.
dc.contributor.authorDiniz, A. R.
dc.contributor.authorBorrego, P.
dc.contributor.authorMarcelino, J. M.
dc.contributor.authorWilton, J.
dc.contributor.authorBartólo, I.
dc.contributor.authorClemente, S.
dc.contributor.authorTaveira, N.
dc.date.accessioned2016-10-12T14:19:40Z
dc.date.available2016-10-12T14:19:40Z
dc.date.issued2015-03-22
dc.descriptionPoster presented at the 2015 Keystone Symposia Conference X5: HIV Vaccines. Banff, Alberta, Canada, 22-27 March 2015pt_PT
dc.description.abstract"Development of immunogens that induce broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine field. Recently, we found that bNAbs can be elicited in Balb/c mice against HIV-2 by using a prime-boost vaccination strategy combining recombinant Vaccinia virus expressing a truncated form of the SU glycoprotein and a polypeptide comprising the C2, V3 and C3 envelope regions. We want to test the hypothesis that a similar vaccination strategy can also be effective for HIV-1. We also want to test the hypothesis that envelope glycoproteins derived from ancestral HIV-1 isolates from Angola may induce a broader neutralizing antibody response compared to envelope glycoproteins derived from contemporaneous isolates."pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/15089
dc.language.isoengpt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.subjectAntibodiespt_PT
dc.subjectHIV-1 infected patientspt_PT
dc.subjectAngolapt_PT
dc.subjectPlasmapt_PT
dc.subjectNeutralization activitypt_PT
dc.titleEnvelope C2-V3-C3-specific antibodies from HIV-1 infected patients from Angola correlate with neutralization activity in plasmapt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-FAR%2F115290%2F2009/PT
oaire.citation.conferencePlaceBanff, Alberta, Canadapt_PT
oaire.citation.title2015 Keystone Symposia Conference X5: HIV Vaccinespt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isProjectOfPublicationc3b60260-41c1-4212-93cd-191d5b2e6133
relation.isProjectOfPublicatione63cde82-fa32-4aed-90e7-c9443427f2e1
relation.isProjectOfPublication15aded3d-70a1-4e02-8508-f5e6a4e56f9a
relation.isProjectOfPublication.latestForDiscoveryc3b60260-41c1-4212-93cd-191d5b2e6133

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