Envelope C2-V3-C3-specific antibodies from HIV-1 infected patients from Angola correlate with neutralization activity in plasma

Calado, R.; Duarte, J.; Diniz, A. R.; Borrego, P.; Marcelino, J. M.; Wilton, J.; Bartólo, I.; Clemente, S.; Taveira, N.

http://hdl.handle.net/10400.26/15089

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"Development of immunogens that induce broadly neutralizing antibodies (bNAbs) is a major goal in HIV-1 vaccine field. Recently, we found that bNAbs can be elicited in Balb/c mice against HIV-2 by using a prime-boost vaccination strategy combining recombinant Vaccinia virus expressing a truncated form of the SU glycoprotein and a polypeptide comprising the C2, V3 and C3 envelope regions. We want to test the hypothesis that a similar vaccination strategy can also be effective for HIV-1. We also want to test the hypothesis that envelope glycoproteins derived from ancestral HIV-1 isolates from Angola may induce a broader neutralizing antibody response compared to envelope glycoproteins derived from contemporaneous isolates."