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Effects of time-restricted eating on body composition, biomarkers of metabolism, inflammation, circadian system and oxidative stress in overweight and obesity: an exploratory review

2024-11-20Text Embargoed access
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLages, Marlene
dc.contributor.authorCarmo-Silva, Sara
dc.contributor.authorBarros, Renata
dc.contributor.authorGuarino, Maria Pedro
dc.date.accessioned2025-04-01T15:43:25Z
dc.date.available2025-04-01T15:43:25Z
dc.date.issued2024-11-20
dc.description.abstractObesity is a chronic, complex and multi-factorial condition with an increasing prevalence worldwide. Irregular eating schedules might be a contributing factor to these numbers through the dysregulation of the circadian system. Time-restricted eating (TRE), an approach that limits eating windows, has been studied as a strategy to treat obesity, aligning eating occasions with metabolic circadian rhythms. This review aims to provide an overview of the impact of TRE protocols on metabolic, inflammatory, oxidative stress and circadian rhythm biomarkers in people with overweight or obesity. Most studies report significant weight loss following TRE protocols. While glucose levels decreased in nearly all TRE interventions, only a few studies demonstrated statistically significant differences when compared to the control groups. The findings for c-reactive protein and TNF-α were inconsistent, with limited significant differences. Changes in lipid profile changes were variable and generally did not reach statistical significance. Both 4-hour and 6-hour TRE interventions significantly reduced 8-isoprostane levels. Additionally, TRE significantly altered clock gene expression, as well as that of genes associated with metabolic regulation in subcutaneous adipose tissue. While the evidence is still inconsistent, limiting eating to a consistent daily window of 8 to 12 h can improve insulin sensitivity, reduce blood glucose, cholesterol and triglyceride levels and promote weight loss.These effects are likely attributable to both direct metabolic impacts and indirect benefits from weight loss and improved dietary habits. However, data on circadian, inflammatory and specific metabolic biomarkers remain scarce and occasionally contradictory, highlighting the need for further research on these interventions.por
dc.description.sponsorshipPublished by Cambridge University Press on behalf of The Nutrition Society
dc.identifier.citationLages M, Carmo-Silva S, Barros R, and Guarino MP (2025). Effects of time-restricted eating on body composition, biomarkers of metabolism, inflammation, circadian system and oxidative stress in overweight and obesity: an exploratory review. Proceedings of the Nutrition Society, page 1 of 10. doi: 10.1017/S002966512400747X
dc.identifier.doi10.1017/S002966512400747X
dc.identifier.eissn1475-2719
dc.identifier.urihttp://hdl.handle.net/10400.26/57521
dc.language.isoeng
dc.peerreviewedyes
dc.publisherCambridge University Press
dc.relation.hasversionhttps://doi.org/10.1017/S002966512400747X
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCircadian rhythm
dc.subjectChrononutrition
dc.subjectBiomarkers
dc.subjectMealtime
dc.subjectMetabolism
dc.subjectMetabolic syndrome
dc.subjectObesity
dc.titleEffects of time-restricted eating on body composition, biomarkers of metabolism, inflammation, circadian system and oxidative stress in overweight and obesity: an exploratory reviewpor
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage10
oaire.citation.startPage1
oaire.citation.titleProceedings of the Nutrition Society
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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