Publication
Self-assembled PHMB titanium coating enables anti-Fusobacterium nucleatum strategy
| datacite.subject.fos | Ciências Médicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Zhao, Jiangyuan | |
| dc.contributor.author | Jin, Shixin | |
| dc.contributor.author | Delgado, António H. S. | |
| dc.contributor.author | Chen, Zhuofan | |
| dc.contributor.author | Matinlinna, Jukka Pekka | |
| dc.contributor.author | Tsoi, James Kit-Hon | |
| dc.date.accessioned | 2025-10-13T15:47:58Z | |
| dc.date.available | 2025-10-13T15:47:58Z | |
| dc.date.issued | 2021-10 | |
| dc.description.abstract | Fusobacterium nucleatum (F. nucleatum) is a gram-negative obligate anaerobe bacterium that threatens human periodontal health. It can cause many oral diseases, including periodontitis, gingivitis and peri-implantitis, and even some diseases such as colorectal cancer are related to it. This paper aims to develop a novel and simple surface modification method for anti-Fusobacterium nucleatum on titanium, i.e., the material for implants. In this study, different concentrations (0.0–1.0%) of PHMB were dip-coated on the titanium surface. The surface properties were examined with the aid of Scanning electron microscopy, Energy-dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and the antibacterial property against F. nucleatum was investigated using colony-forming unit. It was found that the PHMB successfully formed a self-assembled coating on the titanium surface and the PHMB-coated titanium had a strong capability of inhibiting F. nucleatum. Even though differences were found among the several concentrations, PHMB exhibited promising results as a simple coating strategy for dental implants. | eng |
| dc.identifier.citation | Zhao J, Jin S, Delgado AH, Chen Z, Matinlinna JP, Tsoi JK-H. Self-Assembled PHMB Titanium Coating Enables Anti-Fusobacterium nucleatum Strategy. Coatings. 2021; 11(10):1190. https://doi.org/10.3390/coatings11101190 | |
| dc.identifier.doi | 10.3390/coatings11101190 | |
| dc.identifier.issn | 2079-6412 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/59195 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/coatings11101190 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | polyhexamethylene biguanide | |
| dc.subject | titanium dental implant | |
| dc.subject | peri-implantitis | |
| dc.subject | antimicrobial | |
| dc.title | Self-assembled PHMB titanium coating enables anti-Fusobacterium nucleatum strategy | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 10 | |
| oaire.citation.startPage | 1190 | |
| oaire.citation.title | Coatings | |
| oaire.citation.volume | 11 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |