Publication
Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons
| dc.contributor.author | Correia, Patrícia A | |
| dc.contributor.author | Lottem, Eran | |
| dc.contributor.author | Banerjee, Dhruba | |
| dc.contributor.author | Machado, Ana S | |
| dc.contributor.author | Carey, Megan R | |
| dc.contributor.author | Mainen, Zachary F | |
| dc.date.accessioned | 2018-06-29T15:07:08Z | |
| dc.date.available | 2018-06-29T15:07:08Z | |
| dc.date.issued | 2017-02-14 | |
| dc.description.abstract | Serotonin (5-HT) is associated with mood and motivation but the function of endogenous 5-HT remains controversial. Here, we studied the impact of phasic optogenetic activation of 5-HT neurons in mice over time scales from seconds to weeks. We found that activating dorsal raphe nucleus (DRN) 5-HT neurons induced a strong suppression of spontaneous locomotor behavior in the open field with rapid kinetics (onset ≤1 s). Inhibition of locomotion was independent of measures of anxiety or motor impairment and could be overcome by strong motivational drive. Repetitive place-contingent pairing of activation caused neither place preference nor aversion. However, repeated 15 min daily stimulation caused a persistent increase in spontaneous locomotion to emerge over three weeks. These results show that 5-HT transients have strong and opposing short and long-term effects on motor behavior that appear to arise from effects on the underlying factors that motivate actions. | pt_PT |
| dc.description.sponsorship | ERC 250334, 5-HT Optogenetic | |
| dc.description.sponsorship | ERC 671251, 5-HT Circuits | |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.7554/eLife.20975 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/23191 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation | SEROTONIN FUNCTION IN BEHAVIOR | |
| dc.relation | UNDERSTANDING THE ROLE OF THE CEREBELLUM IN GAIT COORDINATION | |
| dc.subject | Dorsal Raphe Nucleus | pt_PT |
| dc.subject | Mice | pt_PT |
| dc.subject | Optogenetics | pt_PT |
| dc.subject | Serotonin | pt_PT |
| dc.subject | Locomotion | pt_PT |
| dc.title | Transient inhibition and long-term facilitation of locomotion by phasic optogenetic activation of serotonin neurons | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | SEROTONIN FUNCTION IN BEHAVIOR | |
| oaire.awardTitle | UNDERSTANDING THE ROLE OF THE CEREBELLUM IN GAIT COORDINATION | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F33277%2F2007/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F51210%2F2010/PT | |
| oaire.citation.title | eLife | pt_PT |
| oaire.citation.volume | 6 | pt_PT |
| oaire.fundingStream | FARH | |
| oaire.fundingStream | FARH | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 62c744bd-03bc-475a-8b88-cb1756419127 | |
| relation.isProjectOfPublication | a5d89c9c-a2ec-46de-acc2-df4c20817d49 | |
| relation.isProjectOfPublication.latestForDiscovery | 62c744bd-03bc-475a-8b88-cb1756419127 |