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Transcutaneous auricular vagus nerve stimulation modulates masseter muscle activity, pain perception, and anxiety levels in university students : a double-blind, randomized, controlled clinical trial

2024-07Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFerreira, Luciano Maia Alves
dc.contributor.authorBrites, Ricardo
dc.contributor.authorFraião, Gonçalo
dc.contributor.authorPereira, Gonçalo Pereira
dc.contributor.authorFernandes, Henrique
dc.contributor.authorBrito, José Américo Almeida de
dc.contributor.authorGeneroso, Laura Pereira
dc.contributor.authorCapello, Maria Gabriela Maziero
dc.contributor.authorPereira, Gabrielly Santos
dc.contributor.authorScoz, Robson Dias
dc.contributor.authorSilva, Josie Resende Torres
dc.contributor.authorSilva, Marcelo Lourenço
dc.date.accessioned2026-04-27T09:38:08Z
dc.date.available2026-04-27T09:38:08Z
dc.date.issued2024-07
dc.description.abstractIntroduction: Chronic anxiety is a statemarked by sustained activation of the masseter muscle, manifesting in both mental and physical strain. This prolonged tension can significantly impact mental wellbeing and cognitive abilities, posing a risk for a range of health complications. This double-blind, randomized, controlled clinical trial investigated the impact of transcutaneous auricular vagus nerve stimulation (TAVNS) on masseter muscle activity, pressure pain threshold (PPT), and anxiety levels in university students with elevated anxiety. Methods: Forty-two participants meeting inclusion criteria were randomly assigned to either active TAVNS or sham TAVNS groups. Various parameters, including masseter muscle electromyographic (EMG) signals, PPT, and Beck Anxiety Inventory (BAI) scores, were assessed before pretreatment, immediately after the intervention week, and 2 weeks follow-up. Results: Active TAVNS significantly reduced both left and right masseter activation during resting mandibular position, persisting for 2 weeks post-intervention. Additionally, TAVNS induced a lasting decrease in both left and right masseter PPT, indicative of altered pain perception. Notably, BAI scores showed a substantial reduction, emphasizing TAVNS as a potential intervention for anxiety, with effects maintained at the 2-week follow-up. Discussion: This study provides comprehensive insights into the multifaceted effects of TAVNS on physiological and psychological aspects associated with anxiety in university students. The promising results underscore TAVNS as a potential neuromodulatory intervention for anxiety-related conditions, warranting further research and clinical exploration.eng
dc.identifier.citationFerreira LMA, Brites R, Fraião G, Pereira G, Fernandes H, de Brito JAA, Pereira Generoso L, Maziero Capello MG, Pereira GS, Scoz RD, Silva JRT and Silva ML (2024) Transcutaneous auricular vagus nerve stimulation modulates masseter muscle activity, pain perception, and anxiety levels in university students: a double-blind, randomized, controlled clinical trial. Front. Integr. Neurosci. 18:1422312. doi: 10.3389/fnint.2024.1422312
dc.identifier.doi10.3389/fnint.2024.1422312
dc.identifier.issn1662-5145
dc.identifier.urihttp://hdl.handle.net/10400.26/62871
dc.language.isoeng
dc.peerreviewedyes
dc.publisherFrontiers Media
dc.relation.hasversionhttps://doi.org/10.3389/fnint.2024.1422312
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjecttranscutaneous auricular vagus nerve stimulation (TAVNS)
dc.subjectanxiety
dc.subjectmasseter muscle activation
dc.subjectpain
dc.subjectneuromodulation
dc.titleTranscutaneous auricular vagus nerve stimulation modulates masseter muscle activity, pain perception, and anxiety levels in university students : a double-blind, randomized, controlled clinical trialeng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.startPage1422312
oaire.citation.titleFrontiers in Integrative Neuroscience
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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