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Oxidative stress function in women over 40 years of age, considering their lifestyle

2017-03Journal article Open access
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dc.contributor.authorMota, Maria Paula Gonçalves
dc.contributor.authorSantos, Zirlene
dc.contributor.authorSoares, Jorge
dc.contributor.authorPereira, A
dc.contributor.authorFonseca, Sandra
dc.contributor.authorPeixoto, Francisco
dc.contributor.authorGaivão, Isabel
dc.contributor.authorOliveira, Maria
dc.date.accessioned2018-04-27T10:06:13Z
dc.date.available2018-04-27T10:06:13Z
dc.date.issued2017-03
dc.description.abstractAging is dependent on biological processes that determine the aging of the organism at the cellular level. The Oxidative Stress Theory of Aging might explain some of the age-related changes in cell macromolecules. Moreover, exposome and lifestyle may also induce changes in cell damage induced by oxidative stress. The aim of the present study was to analyze the related redox changes in lymphocyte function of healthy women over 40 years old. Three groups: younger (YG: 40–49 years), middle aged (MAG: 50–59 years), and older (OG: ≥60 years) were evaluated on anthropometric variables, blood pressure, cardiovascular fitness, lifestyle habits, perceived stress, DNA damage, malondialdehyde, catalase activity, and total antioxidant capacity. Physical activity and cardiovascular fitness were significantly higher in YG and MAG as compared to the OG. Systolic blood pressure increased significantly with group age. Frequency and total amount of alcohol intake were lower in the OG and higher in the MAG. No significant differences were observed between the three groups in oxidative stress parameters. Only alcohol consumption was associated with the higher DNA FPG-sensitive sites, and only in the YG (p < 0.05). Healthy lifestyle is critical to avoiding major ailments associated with aging. This may be inferred from the lack of significant differences in the various oxidative stress parameters measured in the healthy women over the age of 40 who took part in the study. Conscious lifestyle behaviors (decrease in alcohol and smoking habits) could have impaired the expected age-related oxidative stress increase.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMota, M. P. G.; Santos, Z.; Soares, J.; Pereira, A.; Fonseca, S.; Peixoto, F.; Gaivão, I.; Oliveira, M. (2017). Oxidative stress function in women over 40 years of age, considering their lifestyle. Frontiers in Endocrinology, 8:48, 1-6.pt_PT
dc.identifier.doihttps://doi.org/10.3389/fendo.2017.00048pt_PT
dc.identifier.issn1664-2394
dc.identifier.urihttp://hdl.handle.net/10400.26/22599
dc.language.isoengen
dc.peerreviewedyesen
dc.publisherUniversity of Bolognaen
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fendo.2017.00048/fullpt_PT
dc.subjectAgingen
dc.subjectLipid peroxidationen
dc.subjectDNA damageen
dc.subjectOxidative stressen
dc.subjectLifestyleen
dc.subjectCardiovascular fitnessen
dc.titleOxidative stress function in women over 40 years of age, considering their lifestyleen
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Endocrinologyen
oaire.citation.volume8, art. 48pt_PT
person.familyNameFátima
person.givenNameAna
person.identifier.ciencia-id4C1E-4A90-1813
rcaap.rightsopenAccessen
rcaap.typearticleen
relation.isAuthorOfPublication6691e41b-4ba4-403c-b8b4-355629b1c84a
relation.isAuthorOfPublication.latestForDiscovery6691e41b-4ba4-403c-b8b4-355629b1c84a

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