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Screening of recently seized new psychoactive substances in urine of potential consumers and urban wastewater

2017Conference object Open access
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dc.contributor.authorCelma, Alberto
dc.contributor.authorBijlsma, Lubertus
dc.contributor.authorSancho, Juan V.
dc.contributor.authorHernandez, Felix
dc.contributor.authorDias, Mário
dc.contributor.authorSimões, Susana
dc.contributor.authorSalgueiro, Noelia
dc.contributor.authorCastiglioni, Sara
dc.contributor.authorZuccato, Ettore
dc.date.accessioned2021-08-11T16:16:38Z
dc.date.available2021-08-11T16:16:38Z
dc.date.issued2017
dc.descriptionPoster apresentado no VIII Meeting of the Spanish Mass Spectrometry Society (SEEM), 2017, Barcelona,Espanhapt_PT
dc.description.abstractNewPsychoactive Substances (NPS) areconstantly being developed as legalsubstitution of traditional drugs of abuse.Although the traditional drugs maintain popular, new drugs are regularly introduced, changing the drug market ceaselessly. Monitoring NPS and its consumption is challengingas these compoundsare normally missed in routine drug analysis. Users do often not exactly know what they consume andinformation available islimitedof what is being sold. Furthermore, very little information exists onmetabolism of these newly introduced NPS. This highlights the needof applying a strategic workflow making use of modernanalytical techniques to face this novel public health safety challenge.The workflowpresented in this work consists of three stages: i)the creation of a databaseincluding approximately 200 NPS. These NPS wererecently reported to the National Early Warning Systems (EWS) ofSpain andItaly and the EWS of the European Monitoring Center for Drugsand Drug Addiction (EMCDDA). ii) The collection of urine samples of individuals suspected of drug consumption, pooled urine samples from festivals and urban wastewater samples. iii) The screening of NPS using ultra-high performance liquid chromatography coupled to high resolution massspectrometry with a hybrid quadrupole time-of-flight mass analyzer. Although the database is under constant development,including NPS reported to be present in wastewaters around Europe, new compounds appearing in the market, as well as metabolites reported in the literature, the workflow applied allowed the detection of several unchanged NPS in urine and pooled urine samples. In several cases, NPSwere also detected in wastewater samples, which indicatesthat consumptionof some of these compounds is elevated. The absence of reference standards for several NPS found, as well as for some NPS metabolites, made it unfeasible the full confirmation of some compounds in the urine/wastewater samples analyzed. However, accurate-mass full-spectrum data provided by HRMS allowed their tentative identification with high degree of reliability. The subsequent acquisition of reference standards, when available, will allow the unequivocal confirmation of their identity.pt_PT
dc.description.sponsorshipHOME/2014/JDRU/AG/DRUG/7086
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/37297
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectNew Psychoactive Substancespt_PT
dc.subjectUrban Wastewaterpt_PT
dc.subjectUrinept_PT
dc.subjectSubstance Abuse Detectionpt_PT
dc.titleScreening of recently seized new psychoactive substances in urine of potential consumers and urban wastewaterpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceBarcelona, Espanhapt_PT
oaire.citation.titleVIII Meeting of the Spanish Mass Spectrometry Society (SEEM).pt_PT
person.familyNameDias
person.familyNameSimões
person.givenNameMário
person.givenNameSusana
person.identifier.orcid0000-0002-5900-5899
person.identifier.orcid0000-0002-9457-1546
person.identifier.scopus-author-id26221673200
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationb24227f2-a261-4e33-ab53-3edf34744335
relation.isAuthorOfPublicationd0a1e3e3-4d0e-49b5-804e-a55e700f8d22
relation.isAuthorOfPublication.latestForDiscoveryb24227f2-a261-4e33-ab53-3edf34744335

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