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Is lowering stimulation frequency a feasible option for subthalamic deep brain stimulation in Parkinson's disease patients with dysarthria?

2019-04-24Journal article Restricted access
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dc.contributor.authorFabbri, Margherita
dc.contributor.authorZibetti, Maurizio
dc.contributor.authorFerrero, Giulia
dc.contributor.authorAccornero, Anna
dc.contributor.authorGuimarães, Isabel
dc.contributor.authorRizzone, Mario Giorgio
dc.contributor.authorRomagnolo, Alberto
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorLopiano, Leonardo
dc.date.accessioned2022-03-30T16:44:02Z
dc.date.available2022-03-30T16:44:02Z
dc.date.issued2019-04-24
dc.description.abstractBackground: The long-term effect of subthalamic nucleus deep brain stimulation (STN-DBS) on dysarthria can be detrimental. A transient beneficial effect of low-frequency stimulation (LFS) has been reported. Objective: to investigate if the magnitude of dysarthria could predict the effect of LFS on speech in STN-DBS PD patients and to verify whether the benefit is maintained over time. Methods: a cohort study, comparing 10 PD patients with severe speech impairment (MDS-UPDRS item 3.1≥3) with 10 PD patients with mild speech impairment (MDS-UPDRS item 3.1≤2), all submitted to STN-DBS. Patients were tested in: MED OFF/STIM OFF, MED OFF/STIM ON (130 Hz, high frequency stimulation [HFS]), MED OFF/STIM ON (60 Hz - LFS) and MED ON with both HFS and LFS. The following was assessed in all conditions: voice (fundamental frequency and jitter), speech (articulatory diadochokinesis [DDK], pitch variability, rate and intelligibility) and motor performance (MDS-UPDRS-III). Results: LFS compared to no stimulation and HFS, in the absence of L-dopa effect, significantly improved DDK and speech intelligibility for sentence, among patients with severe speech impairment. During the L-dopa effect, comparing LFS vs. HFS, there was a significant improvement of speech intelligibility in both groups. Five patients with severe speech impairment opted to maintain LFS. After six months, speech benefit was maintained but treatment adjustments were required. Conclusions: LFS may offer both an immediate and long-lasting improvement of speech in a subgroup of STNDBS patients with severe speech impairment during HFS. Nevertheless, its effect on motor symptoms may not be preserved over time.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doihttps://doi.org/10.1016/j.parkreldis.2019.04.018pt_PT
dc.identifier.issn1873-5126
dc.identifier.urihttp://hdl.handle.net/10400.26/39948
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectDeep brain stimulationpt_PT
dc.subjectLow frequency stimulationpt_PT
dc.subjectDysarthriapt_PT
dc.titleIs lowering stimulation frequency a feasible option for subthalamic deep brain stimulation in Parkinson's disease patients with dysarthria?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage248pt_PT
oaire.citation.issue2019pt_PT
oaire.citation.startPage242pt_PT
oaire.citation.titleParkinsonism and Related Disorderspt_PT
oaire.citation.volume64
person.familyNameGuimarães
person.givenNameIsabel
person.identifier548796
person.identifier.ciencia-idF014-BFD6-49C2
person.identifier.orcid0000-0001-8524-8731
person.identifier.scopus-author-id24586862700
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdc9a77a2-eecf-4d30-88fa-4200275eccf5
relation.isAuthorOfPublication.latestForDiscoverydc9a77a2-eecf-4d30-88fa-4200275eccf5

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