Repository logo
 
Publication

Lateralization of the visual word form area in patients with alexia after stroke

2018-09Conference object Open access
Simple item page
dc.contributor.authorTello Rodrigues, Inês
dc.contributor.authorCanário, Nádia
dc.contributor.authorCastro-Caldas, Alexandre
dc.date.accessioned2022-04-05T14:24:57Z
dc.date.available2022-04-05T14:24:57Z
dc.date.issued2018-09
dc.description.abstractBackground Knowledge of the process by which visual information is integrated into the brain reading system promotes a better understanding of writing and reading models. Objective This study aimed to use functional Magnetic Resonance Imaging (fMRI) to explore whether the Blood-oxygen-level dependent (BOLD) contrast imaging patterns, of putative cortical region of the Visual Word Form Area (VWFA), are distinct in aphasia patients with moder- ate and severe alexia. Methods Twelve chronic stroke patients (5 patients with severe alexia and 7 pa- tients with moderate alexia) were included. A word categorization task was used to examine responses in the VWFA and its right homolog re- gion. Patients performed a semantic decision task in which words were contrasted with non-verbal fonts to assess the lateralization of reading ability in the ventral occipitotemporal region. Results A fixed effects (FFX) general linear model (GLM) multi-study from the contrast of patients with moderate alexia and those with severe alexia (FDR, p = 0.05, corrected for multiples comparisons using a Threshold Estimator plugin (1000 Monte Carlo simulations), was per- formed. Activation of the left VWFA was robust in patients with mod- erate alexia. Aphasia patients with severe reading deficits also activated the right homolog VWFA. Conclusions This bilateral activation pattern only in patients with severe alexia could be interpreted as a result of reduced recruitment of the left VWFA for reading tasks due to the severe reading deficit. This study provides some new insights about reading pathways and possible neuroplasti- city mechanisms in aphasia patients with alexia. Additional reports could explore the predictive value of right VWFA activation for reading recovery and aid language therapy in patients with aphasia.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.doihttps://www.researchgate.net/publication/329044084_Lateralization_of_the_visual_word_form_area_in_patients_with_alexia_after_strokept_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/40117
dc.language.isoengpt_PT
dc.subjectStrokept_PT
dc.subjectAlexiapt_PT
dc.subjectAphasiapt_PT
dc.titleLateralization of the visual word form area in patients with alexia after strokept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLeiriapt_PT
oaire.citation.endPage155pt_PT
oaire.citation.issueP130pt_PT
oaire.citation.startPage155pt_PT
oaire.citation.title4th IPLeiria’s International Health Congresspt_PT
oaire.citation.volumeSetembro de 2018pt_PT
person.familyNameR. M. Rodrigues
person.givenNameInês
person.identifier.ciencia-id3B17-00D5-0D54
person.identifier.orcid0000-0001-9953-8529
person.identifier.scopus-author-id56173937900
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication5cf43380-4fe1-4393-adc1-c914c3dec3b9
relation.isAuthorOfPublication.latestForDiscovery5cf43380-4fe1-4393-adc1-c914c3dec3b9

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
proceedingsLEIRIA.pdf
Size:
3.44 MB
Format:
Adobe Portable Document Format
Download

Collections

ESSA - TF - Congressos e eventos científicos (inclui comunicações e posters em atas de conferências/encontros científicos)