Loading...
Publication
Obesidade felina e o papel da microbiota intestinal nesta doença
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 2.75 MB | Adobe PDF |
Authors
Advisor(s)
Abstract(s)
A obesidade é uma patologia que afeta cerca de 30 a 50% dos gatos “indoor”. A obesidade é uma
doença multifactorial que se desenvolve particularmente em gatos machos, castrados, de meia-idade
e com um estilo de vida “indoor”. Isto ocorre, principalmente, devido à baixa atividade física aliada à
dieta ad libitum frequentemente cedida aos gatos “indoor”, causando uma deposição excessiva de
triglicéridos no tecido adiposo branco, que, por sua vez, promove uma desregulação na secreção de
adipocinas circulantes (leptina e adiponectina). Estes desequilíbrios nas adipocinas tem inúmeras
consequências, nomeadamente uma diminuição da sensação de saciedade, uma redução dos gastos
de energia e dos mecanismos de inibição da inflamação, o que, no seu conjunto, favorece o
desenvolvimento de obesidade.
Por outro lado, estudos recentes revelam que gatos obesos “indoor” apresentam uma menor
diversidade microbiana intestinal, o que leva a um desequilíbrio na produção dos metabolitos
bacterianos sintetizados e benéficos para a saúde do hospedeiro, tais como butirato, cobalamina e
folato.
Além disto, tem-se verificado que algumas dietas recorrendo à associação de pré, pró ou pós-bióticos
são promissoras no combate à obesidade, regulando a composição da microbiota intestinal dos felinos
domésticos. O transplante fecal tem revelado ser outra estratégia com potencial para restaurar a
diversidade microbiana em animais obesos com disbiose intestinal, ainda pouco explorada no contexto
da medicina veterinária.
Obesity is a disease affecting about 30 to 50% of indoor cats. Obesity is a multifactorial disease that develops particularly in male, neutered, middle-aged cats with an "indoor" lifestyle. This occurs mainly due to the low physical activity combined with the ad libitum diet often given to indoor cats, causing an excessive deposition of triglycerides in the white adipose tissue, which, in turn, promotes a dysregulation of circulating adipokines secretion (leptin and adiponectin). These imbalances in adipokines levels have numerous consequences, including a decrease in the satiety feeling, a reduction of the energy expenditure and a reduction of the anti-inflammatory mechanisms, promoting the development of obesity. On the other hand, recent studies reveal that obese indoor cats have a lower intestinal microbial diversity, which leads to an imbalance in the production of several bacterial metabolites, such as butyrate, cobalamin and folate, which are highly beneficial to host health. In addition, it has been verified that some diets associated with pre, pro or postbiotics are promising in the fight against obesity, by regulating intestinal microbiota composition of domestic cats. Fecal transplantation is another strategy with high potential to restore microbial diversity in obese animals, which has been poor explored in veterinary medicine context.
Obesity is a disease affecting about 30 to 50% of indoor cats. Obesity is a multifactorial disease that develops particularly in male, neutered, middle-aged cats with an "indoor" lifestyle. This occurs mainly due to the low physical activity combined with the ad libitum diet often given to indoor cats, causing an excessive deposition of triglycerides in the white adipose tissue, which, in turn, promotes a dysregulation of circulating adipokines secretion (leptin and adiponectin). These imbalances in adipokines levels have numerous consequences, including a decrease in the satiety feeling, a reduction of the energy expenditure and a reduction of the anti-inflammatory mechanisms, promoting the development of obesity. On the other hand, recent studies reveal that obese indoor cats have a lower intestinal microbial diversity, which leads to an imbalance in the production of several bacterial metabolites, such as butyrate, cobalamin and folate, which are highly beneficial to host health. In addition, it has been verified that some diets associated with pre, pro or postbiotics are promising in the fight against obesity, by regulating intestinal microbiota composition of domestic cats. Fecal transplantation is another strategy with high potential to restore microbial diversity in obese animals, which has been poor explored in veterinary medicine context.
Description
Keywords
Gato Medicina veterinária Microbiota intestinal Obesidade Pós-bióticos Prebióticos Probióticos Transplante fecal Cat Fecal transplantation Gut microbiota Obesity Postbiotics Prebiotics Probiotics Veterinary medicine