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Relationship between blood and standard biochemistry levels with periodontitis in Parkinson’s disease patients: data from the NHANES 2011–2012

2020Journal article Open access
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dc.contributor.authorBotelho, João
dc.contributor.authorLyra, Patrícia
dc.contributor.authorProença, Luis
dc.contributor.authorGodinho, Catarina
dc.contributor.authorMendes, José João
dc.contributor.authorMachado, Vanessa
dc.date.accessioned2022-04-04T13:17:24Z
dc.date.available2022-04-04T13:17:24Z
dc.date.issued2020
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractPeople with Parkinson’s Disease (PD) are associated with the presence of periodontitis. We aimed to compare blood and standard biochemical surrogates of PD patients diagnosed with periodontitis with PD individuals without periodontitis. This retrospective cohort study used a sample from the National Health and Nutrition Examination Survey (NHANES) 2011–2012 that underwent periodontal diagnosis (n = 3669). PD participants were identified through specific PD reported medications. Periodontitis was defined according to the 2012 case definition, using periodontal examination data provided. Then, we compared blood levels and standard chemical laboratory profiles of PD patients according to the presence of periodontitis. Multivariable regression was used to explore this dataset and identify relevant variables towards the presence of periodontitis. According to the medication report, 37 participants were eligible, 29 were secure and 8 were unsecure PD medications regimens. Overall, PD cases with periodontitis presented increased levels of White Blood Cells (WBC) (p = 0.002), Basophils (p = 0.045) and Segmented neutrophils (p = 0.009), and also, lower levels of Total Bilirubin (p = 0.018). In the PD secure medication group, a significant difference was found for WBC (p = 0.002) and Segmented neutrophils (p = 0.002) for the periodontitis group. Further, WBC might be a discriminating factor towards periodontitis in the global sample. In the secure PD medication, we found gender, segmented neutrophils and Vitamin D2 to be potential discriminative variables towards periodontitis. Thus, periodontitis showed association with leukocyte levels alterations in PD patients, and therefore with potential systemic changes and predictive value. Furthermore, Vitamin D2 and gender showed to be associated with periodontitis in with secure medication for PD. Future studies should assess in more detail the potential systemic repercussion of the presence of periodontitis in PD patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBotelho J, Lyra P, Proença L, Godinho C, Mendes JJ, Machado V. Relationship between Blood and Standard Biochemistry Levels with Periodontitis in Parkinson’s Disease Patients: Data from the NHANES 2011–2012. Journal of Personalized Medicine. 2020; 10(3):69. https://doi.org/10.3390/jpm10030069pt_PT
dc.identifier.doi10.3390/jpm10030069pt_PT
dc.identifier.issn2075-4426
dc.identifier.urihttp://hdl.handle.net/10400.26/40037
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://doi.org/10.3390/jpm10030069pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectMovement disorderspt_PT
dc.subjectPeriodontitispt_PT
dc.subjectPeriodontal diseasept_PT
dc.subjectHematologic testspt_PT
dc.subjectVitamin Dpt_PT
dc.subjectOral healthpt_PT
dc.titleRelationship between blood and standard biochemistry levels with periodontitis in Parkinson’s disease patients: data from the NHANES 2011–2012pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage69pt_PT
oaire.citation.titleJournal of Personalized Medicinept_PT
oaire.citation.volume10(3)pt_PT
person.familyNameBotelho
person.familyNameProença
person.familyNameGodinho
person.familyNameBaltazar Mendes
person.familyNameMachado
person.givenNameJoão
person.givenNameLuis
person.givenNameCatarina
person.givenNameJosé João
person.givenNameVanessa
person.identifierI-4587-2016
person.identifierN-6604-2013
person.identifierABF-6650-2020
person.identifier.ciencia-id461D-04AF-2777
person.identifier.ciencia-idC01D-DE3F-3C63
person.identifier.ciencia-id3919-33C7-AAF3
person.identifier.ciencia-id0916-5CC6-EE37
person.identifier.ciencia-id7318-90D4-B716
person.identifier.orcid0000-0002-1019-8263
person.identifier.orcid0000-0002-8482-5936
person.identifier.orcid0000-0003-2304-3129
person.identifier.orcid0000-0003-0167-4077
person.identifier.orcid0000-0003-2503-260X
person.identifier.scopus-author-id57193508268
person.identifier.scopus-author-id6603543544
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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