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Effects of large pressure amplitude low frequency noise in the parotid gland perivasculo-ductal connective tissue
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Advisor(s)
Abstract(s)
"Introduction: In tissues and organs exposed to large pressure amplitude low frequency noise fibrosis occurs in the absence of inflammatory
signs, which is thought to be a protective response. In the parotid gland the perivasculo-ductal connective tissue surrounds
arteries, veins and the ductal tree. Perivasculo-ductal connective tissue is believed to function as a mechanical stabilizer of the glandular
tissue.
Material and Methods: In order to quantify the proliferation of perivasculo-ductal connective tissue in large pressure amplitude low
frequency noise-exposed rats we used sixty Wistar rats which were equally divided into 6 groups. One group kept in silence, and the
remaining five exposed to continuous large pressure amplitude low frequency noise: g1-168h (1 week); g2-504h (3 weeks); g3-840h
(5 weeks); g4-1512h (9 weeks); and g5-2184h (13 weeks). After exposure, parotid glands were removed and the perivasculo-ductal
connective tissue area was measured in all groups. We applied ANOVA statistical analysis, using SPSS 13.0.
Results: The global trend is an increase in the average perivasculo-ductal connective tissue areas, that develops linearly and significantly
with large pressure amplitude low frequency noise exposure time (p < 0.001).
Discussion: It has been suggested that the biological response to large pressure amplitude low frequency noise exposure is associated
with the need to maintain structural integrity. The structural reinforcement would be achieved by increased perivasculo-ductal
connective tissue.
Conclusions: Hence, these results show that in response to large pressure amplitude low frequency noise exposure, rat parotid glands
increase their perivasculo-ductal connective tissue."
Description
Keywords
Fibrillar collagens Connective tissue Parotid gland Rats
Citation
Acta Med Port 2013 May-Jun;26(3):237-242