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Microextraction by packed sorbent for the determination of selected synthetic cathinones and 2C-P in hair

2025Artigo científico Acesso aberto
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datacite.subject.fosCiências Naturais::Ciências Químicas
dc.contributor.authorAna Y. Simão
dc.contributor.authorda Silva Rosendo, Luana May
dc.contributor.authorDias Dinis, Pedro Alexandre
dc.contributor.authorMargalho, Cláudia
dc.contributor.authorAndraus, Maristela
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2026-01-23T19:41:09Z
dc.date.available2026-01-23T19:41:09Z
dc.date.issued2025
dc.description.abstractNew psychoactive substances (NPS), including synthetic cathinones and phenethylamines, pose significant challenges due to their evolving chemical structures and health impacts. This study aimed to optimize and validate a methodology for detecting and quantifying a number of synthetic cathinones [methylone, ethylone, pentedrone, 4-chloroethcathinone (4-CEC), penthylone, α-pyrrolidinopentiophenone (α-PVP), 3,4-methylenedioxypyrovalerone (MDPV), 4‑chloro-α-pyrrolidinovalerophenone (4-Cl-α-PVP), as well as phenethylamine 2,5-dimethoxy-4(n)-propylphenethylamine (2C-P)], in hair samples using microextraction by packed sorbent (MEPS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We developed an environmentally friendly and cost-effective MEPS procedure, which was validated for selectivity, linearity, precision, accuracy, and recovery. Results demonstrated that the method effectively detects analytes with limits of quantification as low as 10 pg/mg. The method successfully identifies MDPV in concentrations consistent with those observed in chronic and acute drug consumption cases, proving its suitability in forensic and clinical toxicology. This approach offers a robust solution for forensic and clinical applications, by combining efficient sample clean-up with precise analytical capabilities.eng
dc.identifier.citationSimão AY, Rosendo LM, Dinis P, Margalho C, Barroso M, Gallardo E. Microextraction by packed sorbent for the determination of selected synthetic cathinones and 2C-P in hair. Advances in Sample Preparation. 2025; 14: 100175
dc.identifier.doi10.1016/j.sampre.2025.100175
dc.identifier.issn2772-5820
dc.identifier.urihttp://hdl.handle.net/10400.26/61167
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationhttps://doi.org/10.544 99/UIDB/00709/2020
dc.relationhttps://doi.org/10.54499/UIDP/00709/20 20
dc.relationhttps://doi.org/10.54499/2020.09070.BD
dc.relation.hasversionhttps://doi.org/10.1016/j.sampre.2025.100175
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHair
dc.subjectSynthetic cathinones
dc.subjectPhenethylamines
dc.subjectNew psychoactive substances
dc.subjectMicroextraction by packed sorbent
dc.subjectLC-MS/MS
dc.titleMicroextraction by packed sorbent for the determination of selected synthetic cathinones and 2C-P in haireng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8
oaire.citation.startPage1
oaire.citation.titleAdvances in Sample Preparation
oaire.citation.volume14
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSimão
person.familyNameda Silva Rosendo
person.familyNameDias Dinis
person.familyNameMargalho
person.familyNameAndraus
person.familyNameBarroso
person.familyNameGallardo
person.givenNameAna Aysa
person.givenNameLuana May
person.givenNamePedro Alexandre
person.givenNameCláudia
person.givenNameMaristela
person.givenNameMário
person.givenNameEugenia
person.identifier.ciencia-id4E12-377B-7569
person.identifier.ciencia-id1A17-DAC1-3C27
person.identifier.ciencia-idA211-521D-90CA
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.ciencia-idF617-5CA5-EF61
person.identifier.orcid0000-0003-3199-1866
person.identifier.orcid0000-0002-0461-8540
person.identifier.orcid0009-0007-5443-1411
person.identifier.orcid0000-0003-1661-0367
person.identifier.orcid0000-0002-6611-0443
person.identifier.orcid0000-0001-8848-2734
person.identifier.orcid0000-0002-1802-8998
person.identifier.ridKII-2916-2024
person.identifier.scopus-author-id57218392172
person.identifier.scopus-author-id8655072100
person.identifier.scopus-author-id35329243100
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