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Microextraction by packed sorbent for the determination of selected synthetic cathinones and 2C-P in hair
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Orientador(es)
Resumo(s)
New psychoactive substances (NPS), including synthetic cathinones and phenethylamines, pose significant
challenges due to their evolving chemical structures and health impacts. This study aimed to optimize and
validate a methodology for detecting and quantifying a number of synthetic cathinones [methylone, ethylone,
pentedrone, 4-chloroethcathinone (4-CEC), penthylone, α-pyrrolidinopentiophenone (α-PVP), 3,4-methylenedioxypyrovalerone
(MDPV), 4‑chloro-α-pyrrolidinovalerophenone (4-Cl-α-PVP), as well as phenethylamine
2,5-dimethoxy-4(n)-propylphenethylamine (2C-P)], in hair samples using microextraction by packed sorbent
(MEPS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). We developed an environmentally
friendly and cost-effective MEPS procedure, which was validated for selectivity, linearity, precision, accuracy,
and recovery. Results demonstrated that the method effectively detects analytes with limits of quantification as
low as 10 pg/mg. The method successfully identifies MDPV in concentrations consistent with those observed in
chronic and acute drug consumption cases, proving its suitability in forensic and clinical toxicology. This
approach offers a robust solution for forensic and clinical applications, by combining efficient sample clean-up
with precise analytical capabilities.
Descrição
Palavras-chave
Hair Synthetic cathinones Phenethylamines New psychoactive substances Microextraction by packed sorbent LC-MS/MS
Contexto Educativo
Citação
Simão AY, Rosendo LM, Dinis P, Margalho C, Barroso M, Gallardo E. Microextraction by packed sorbent for the determination of selected synthetic cathinones and 2C-P in hair. Advances in Sample Preparation. 2025; 14: 100175
Editora
Elsevier