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A eletroquimioterapia no tratamento de neoplasias em gatos
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Abstract(s)
A eletroquimioterapia (EQT) é um tratamento que combina a administração sistémica ou
local de fármacos pouco permeáveis, como a bleomicina ou a cisplatina e a aplicação de
pulsos elétricos locais. Os pulsos aplicados provocam a eletroporação (EP) da membrana das
células tumorais, o que a torna permeável ao agente quimioterápico administrado,
maximizando a sua concentração intracelular e a sua ação citotóxica. Tem-se destacado na
medicina veterinária pela sua facilidade de aplicação, baixo custo e baixa toxicidade, o que faz
com que esteja a ser incluída como uma das primeiras opções de tratamento, por exemplo no
caso de tumores em locais anatómicos complicados com uma difícil excisão cirúrgica. Tem sido
demonstrada a eficácia da EQT em vários estudos na medicina veterinária, podendo ser
utilizada no tratamento de tumores únicos ou múltiplos, cutâneos, subcutâneos, primários ou
recorrentes, de diferentes tipos histológicos de forma paliativa ou como tratamento adjuvante à
cirurgia. O objetivo deste artigo de revisão é compilar o conhecimento atual sobre o uso de
EQT mais especificamente em gatos, apresentando conclusões gerais sobre os estudos já
realizados e identificando os prós e contras da EQT.
Electrochemotherapy (ECT) is a treatment that combines the systemic or local administration of drugs with low permeability, such as bleomycin or cisplatin and the application of local electrical pulses. The pulses applied provoke the electroporation (EP) of the membrane of the tumor cells, which makes it permeable to the chemotherapeutic agent administered maximizing its intracellular concentration and its cytotoxic action. It has been highlighted in veterinary medicine for its ease of application, low cost and low toxicity, which makes it to be included as a first line of treatment, for example in tumors in anatomical sites complicated with difficult surgical excision. The efficacy of electrochemotherapy in several studies in veterinary medicine has been demonstrated and can be used in the treatment of single or multiple, cutaneous, subcutaneous, primary or recurrent tumors of different histological types in palliative form or as an adjuvant treatment to surgery. The objective of this review article is to compile current knowledge about the use of electrochemotherapy more specifically in cats, presenting general conclusions about the studies already performed and identifying the pros and cons of the ECT.
Electrochemotherapy (ECT) is a treatment that combines the systemic or local administration of drugs with low permeability, such as bleomycin or cisplatin and the application of local electrical pulses. The pulses applied provoke the electroporation (EP) of the membrane of the tumor cells, which makes it permeable to the chemotherapeutic agent administered maximizing its intracellular concentration and its cytotoxic action. It has been highlighted in veterinary medicine for its ease of application, low cost and low toxicity, which makes it to be included as a first line of treatment, for example in tumors in anatomical sites complicated with difficult surgical excision. The efficacy of electrochemotherapy in several studies in veterinary medicine has been demonstrated and can be used in the treatment of single or multiple, cutaneous, subcutaneous, primary or recurrent tumors of different histological types in palliative form or as an adjuvant treatment to surgery. The objective of this review article is to compile current knowledge about the use of electrochemotherapy more specifically in cats, presenting general conclusions about the studies already performed and identifying the pros and cons of the ECT.
Description
Keywords
Gato Tumor Eletroquimioterapia Eletroporação Cat Electrochemotherapy Eletroporation