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Fixação de fluoreto no esmalte dentário com diferentes pastas dentífricas : um estudo piloto
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Resumo(s)
Objetivos: Avaliar a absorção de flúor pelo esmalte dentário a partir de cinco formulações distintas de pastas dentífricas.
Materiais e métodos: Sessenta molares permanentes humanos foram seccionados longitudinalmente, obtendo-se dois espécimes de esmalte por dente. A superfície vestibular foi utilizada como espécime experimental e a superfície lingual/palatina como controlo. Os espécimes experimentais foram distribuídos aleatoriamente por cinco grupos (A-E) (n = 12) de acordo com o agente fluoretado presente nas pastas dentífricas: hidrofluoreto de nicometanol (A), fluoreto de sódio (B), fluoreto de estanho combinado com fluoreto de sódio (C), fluoreto de amina (D) e monofluorofosfato de sódio (E). Após uma fase inicial de desmineralização, os espécimes foram imersos em suspensões das respetivas pastas dentífricas, enquanto os controlos permaneceram em água desionizada. A absorção de flúor foi determinada através da técnica de biópsia ácida, através de um elétrodo seletivo de iões fluoreto previamente calibrado. Os dados foram analisados estatisticamente utilizando o teste t de Student e os testes de Kruskal-Wallis, com um nível de significância de 5 %.
Resultados: Os grupos experimentais apresentaram concentrações de flúor superiores às dos respetivos grupos de controlo. Verificaram-se diferenças estatisticamente significativas (p < 0,05) entre os grupos controlo e experimental em todos os grupos, exceto no grupo C (p = 0,096). A comparação entre as diferentes pastas dentífricas revelou diferenças estatisticamente significativas (p < 0,001), tendo o grupo A apresentado valores de absorção de flúor superiores aos observados nos grupos D e E (p < 0,05).
Conclusões: A maioria das pastas dentífricas fluoretadas promoveu a absorção de flúor pelo esmalte dentário, embora o grau de absorção tenha variado de acordo com a formulação do flúor ativo. O hidrofluoridrato de nicometanol apresentou valores mais elevados de absorção de flúor, sugerindo que a biodisponibilidade do flúor depende não apenas da sua concentração, mas também da formulação química.
Objectives: This in vitro study aimed to evaluate enamel fluoride uptake from five different fluoride toothpaste formulations. Materials and methods: Sixty permanent human molars were sectioned longitudinally to obtain enamel specimens, which were randomly allocated into five groups (A-E) (n=12) according to the fluoridating agent present in the toothpaste: nicomethanol hydrofluoride (A), sodium fluoride (B), stannous fluoride combined with sodium fluoride (C), amine fluoride (D), and sodium monofluorophosphate (E). After an initial demineralization phase, the specimens were immersed in suspensions of the respective toothpastes. Fluoride uptake was quantified using an acid biopsy technique, with a previously calibrated fluoride ion-selective electrode. The data were statistically analyzed using Student’s t-test and Kruskal–Wallis tests, with a significance level of 5 %. Results: The experimental groups showed higher fluoride concentrations than their respective control groups. Statistically significant differences (p < 0.05) were observed between the control and experimental groups in all groups except group C (p = 0.096). The comparison between the different toothpastes revealed statistically significant differences (p < 0.001), with group A showing higher fluoride absorption values than those observed in groups D and E (p < 0.05). Conclusions: Most fluoridated toothpastes promoted fluoride absorption by tooth enamel, although the degree of absorption varied depending on the formulation of the active fluoride. Nicomethanol hydrofluoride showed the highest values of fluoride absorption, suggesting that bioavailability of fluoride depends not only on its concentration but also on its chemical formulation.
Objectives: This in vitro study aimed to evaluate enamel fluoride uptake from five different fluoride toothpaste formulations. Materials and methods: Sixty permanent human molars were sectioned longitudinally to obtain enamel specimens, which were randomly allocated into five groups (A-E) (n=12) according to the fluoridating agent present in the toothpaste: nicomethanol hydrofluoride (A), sodium fluoride (B), stannous fluoride combined with sodium fluoride (C), amine fluoride (D), and sodium monofluorophosphate (E). After an initial demineralization phase, the specimens were immersed in suspensions of the respective toothpastes. Fluoride uptake was quantified using an acid biopsy technique, with a previously calibrated fluoride ion-selective electrode. The data were statistically analyzed using Student’s t-test and Kruskal–Wallis tests, with a significance level of 5 %. Results: The experimental groups showed higher fluoride concentrations than their respective control groups. Statistically significant differences (p < 0.05) were observed between the control and experimental groups in all groups except group C (p = 0.096). The comparison between the different toothpastes revealed statistically significant differences (p < 0.001), with group A showing higher fluoride absorption values than those observed in groups D and E (p < 0.05). Conclusions: Most fluoridated toothpastes promoted fluoride absorption by tooth enamel, although the degree of absorption varied depending on the formulation of the active fluoride. Nicomethanol hydrofluoride showed the highest values of fluoride absorption, suggesting that bioavailability of fluoride depends not only on its concentration but also on its chemical formulation.
Descrição
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Palavras-chave
Flúor Remineralização Esmalte Pasta de dentes