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Potencialização dos riscos em pacientes diabéticos infectados pelo SARS-COV-2
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Abstract(s)
A Diabetes Mellitus é uma patologia que atinge milhões de pessoas em todo o mundo e desencadeia alterações nos processos inflamatórios e de coagulação sanguínea, especialmente em quem não trata a doença. Segundo a Organização Mundial de Saúde (OMS) na infecção pelo Sars-CoV-2 (coronavírus), pacientes diabéticos pertencem ao grupo que apresenta maior probabilidade de desenvolver complicações graves. A COVID-19 tornou-se uma pandemia mundial e problemas decorrentes da infecção tem sido atribuídos como uma das principais causas de mortalidade. O objetivo desse trabalho é avaliar o perfil de risco de doentes com Diabetes Mellitus tipo 1 e tipo 2, face à COVID-19. Trata-se de um estudo observacional de coorte retrospectivo. A Diabetes Mellitus é um potencial fator de risco para o agravamento da infecção pelo Sars-CoV-2. A proteína ACE2 está expressa nas células beta-pancreáticas, facilitando a entrada do coronavírus e desse modo alterando o metabolismo da glicose. A tempestade inflamatória de ambas doenças com consequente coagulação descontrolada, disfunção endotelial e desequilíbrio entre processos podem ser fator fundamental para elucidar as características dessa perigosa interação. O paciente diabético infectado pelo Sars-CoV-2 deve ser assistido de uma forma diferenciada, de modo que a equipe multidisciplinar leve em consideração que a maior conexão entre as doenças e possivelmente os maiores riscos são os processos inflamatórios, hipercoagulabilidade e problemas na função pulmonar.
Diabetes Mellitus is a disease that affects millions of people around the world and triggers changes in inflammatory processes and blood clotting, especially in those who do not treat the disease. According to the World Health Organization (WHO) in Sars-CoV-2 (coronavirus) infection, diabetic patients belong to the group that is most likely to develop serious complications. Covid-19 has become a worldwide pandemic and problems arising from the infection have been attributed as one of the main causes of mortality. To evaluate the risk profile of patients with Diabetes Mellitus type 1 and type 2, in view of COVID-19. This is a retrospective observational cohort study. Diabetes Mellitus is a potential risk factor for the worsening of Sars-CoV-2 infection. The ACE2 protein is expressed in pancreatic beta cells, facilitating the entry of the coronavirus and thus altering glucose metabolism. The inflammatory storm of both diseases with consequent uncontrolled coagulation, endothelial dysfunction and imbalance between processes may be a fundamental factor in elucidating the characteristics of this dangerous interaction. The diabetic patient infected with Sars-CoV-2 must be treated in a different way, so that the multidisciplinary team takes into account that the greatest connection between the diseases and possibly the greatest risks are inflammatory processes, hypercoagulability and problems with pulmonary function.
Diabetes Mellitus is a disease that affects millions of people around the world and triggers changes in inflammatory processes and blood clotting, especially in those who do not treat the disease. According to the World Health Organization (WHO) in Sars-CoV-2 (coronavirus) infection, diabetic patients belong to the group that is most likely to develop serious complications. Covid-19 has become a worldwide pandemic and problems arising from the infection have been attributed as one of the main causes of mortality. To evaluate the risk profile of patients with Diabetes Mellitus type 1 and type 2, in view of COVID-19. This is a retrospective observational cohort study. Diabetes Mellitus is a potential risk factor for the worsening of Sars-CoV-2 infection. The ACE2 protein is expressed in pancreatic beta cells, facilitating the entry of the coronavirus and thus altering glucose metabolism. The inflammatory storm of both diseases with consequent uncontrolled coagulation, endothelial dysfunction and imbalance between processes may be a fundamental factor in elucidating the characteristics of this dangerous interaction. The diabetic patient infected with Sars-CoV-2 must be treated in a different way, so that the multidisciplinary team takes into account that the greatest connection between the diseases and possibly the greatest risks are inflammatory processes, hypercoagulability and problems with pulmonary function.
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Keywords
Sars-CoV-2 Diabetes Mellitus Proteína ACE2 Enzima de Conversão de Angiotensina 2 COVID-19