Publicação
Dose-dependent cognitive decline, anxiety, and locomotor impairments induced by doxorubicin : evidence from an animal model
| datacite.subject.fos | Ciências Naturais::Ciências Biológicas | |
| datacite.subject.sdg | 03:Saúde de Qualidade | |
| dc.contributor.author | Amaro-Leal, Ângela | |
| dc.contributor.author | Afonso, Ana I. | |
| dc.contributor.author | Machado, Filipa | |
| dc.contributor.author | Shvachiy, Liana | |
| dc.contributor.author | Rocha, Isabel | |
| dc.contributor.author | Outeiro, Tiago F. | |
| dc.contributor.author | Geraldes, Vera | |
| dc.date.accessioned | 2026-03-23T16:35:30Z | |
| dc.date.available | 2026-03-23T16:35:30Z | |
| dc.date.issued | 2024-11 | |
| dc.description.abstract | Cognitive impairment and anxiety are common side effects of chemotherapy, particularly with the use of doxorubicin (DOX), known as “chemobrain”. This study aimed to examine the dose-dependent effects of DOX on cognitive decline, anxiety, and locomotor activity in healthy female Wistar rats. The rats were divided into groups receiving low (2 mg/kg), intermediate (4 mg/kg), and high (5 mg/kg) doses of DOX for four weeks, alongside a control group. Behavioral tests, including open field, elevated plus maze, and Y-maze tests, assessed anxiety, locomotion, and cognitive performance, while brain tissue analysis evaluated neuroinflammation using markers such as GFAP and Iba-1. The results showed that all doses of DOX induced anxiety-like behavior, reduced locomotion, and caused neuroinflammation in the hippocampus, with more severe effects at higher doses. Notably, high-dose DOX also caused short-term memory deficits. These findings highlight the dose-dependent nature of DOX’s impact on behavior and cognition, suggesting that DOX plays a key role in the development of cognitive symptoms during chemotherapy. Further research is needed to understand the mechanisms behind these effects and to explore potential interventions. | eng |
| dc.identifier.citation | Amaro-Leal Â, Afonso AI, Machado F, Shvachiy L, Rocha I, Outeiro TF, Geraldes V. Dose-Dependent Cognitive Decline, Anxiety, and Locomotor Impairments Induced by Doxorubicin: Evidence from an Animal Model. Biology. 2024; 13(11):939. https://doi.org/10.3390/biology13110939 | |
| dc.identifier.doi | 10.3390/biology13110939 | |
| dc.identifier.issn | 2079-7737 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/62366 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.publisher | MDPI | |
| dc.relation.hasversion | https://doi.org/10.3390/biology13110939 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.subject | doxorubicin | |
| dc.subject | anxiety | |
| dc.subject | chemotherapy-induced cognitive impairment | |
| dc.subject | cognitive dysfunction | |
| dc.title | Dose-dependent cognitive decline, anxiety, and locomotor impairments induced by doxorubicin : evidence from an animal model | eng |
| dc.type | contribution to journal | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 11 | |
| oaire.citation.startPage | 939 | |
| oaire.citation.title | Biology | |
| oaire.citation.volume | 13 | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |