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Orientador(es)
Resumo(s)
This work reports the preliminary development of paroxetine-containing formulations amenable to hot-melt extrusion coupled to fused deposition modelling-based 3D printing. Polymeric matrices were used alone, or added with processing enhancers (e.g., plasticizer and filler). The polymeric formulation containing paroxetine (30% w/w), hydroxypropylcellulose (54% w/w) and excipients (16% w/w of dicalcium dihydrate phosphate, magnesium stearate and triethylcitrate; 10:1:5 ratio) exhibited the most suitable behaviour to be extruded and 3D printed, proving that adjuvants are critical to ensure processing of the formulations.
Descrição
Communication abstract: Proceedings of the 5th International Congress of CiiEM - Reducing inequalities in Health and Society, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from June 16th to 18th, 2021.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Palavras-chave
Extrudability Filament Printability 3D-printed tablet Fused deposition modelling (FDM) Hot melt extrusion (HME) Paroxetine (PRX)
Contexto Educativo
Citação
Figueiredo S, Pinto JF, Carvalho FG, Fernandes AI. Tuning of Paroxetine 3D-Printable Formulations for Fused Deposition Modelling. Medical Sciences Forum. 2021; 5(1):17. https://doi.org/10.3390/msf2021005017
Editora
MDPI