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Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

2021-01-24Journal article Open access
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dc.contributor.authorAmaral, Rita
dc.contributor.authorJácome, Cristina
dc.contributor.authorAlmeida, Rute
dc.contributor.authorPereira, Ana Margarida
dc.contributor.authorAlves-Correia, Magna
dc.contributor.authorMendes, Sandra
dc.contributor.authorRodrigues, José Carlos Cidrais
dc.contributor.authorCarvalho, Joana
dc.contributor.authorAraújo, Luís
dc.contributor.authorCosta, Alberto
dc.contributor.authorSilva, Armandina
dc.contributor.authorTeixeira, Maria Fernanda
dc.contributor.authorFerreira-Magalhães, Manuel
dc.contributor.authorAlves, Rodrigo Rodrigues
dc.contributor.authorMoreira, Ana Sofia
dc.contributor.authorFernandes, Ricardo M.
dc.contributor.authorFerreira, Rosário
dc.contributor.authorPinto, Paula Leiria
dc.contributor.authorNeuparth, Nuno
dc.contributor.authorBordalo, Diana
dc.contributor.authorBom, Ana Todo
dc.contributor.authorCálix, Maria José
dc.contributor.authorFerreira, Tânia
dc.contributor.authorGomes, Joana
dc.contributor.authorVidal, Carmen
dc.contributor.authorMendes, Ana
dc.contributor.authorVasconcelos, Maria João
dc.contributor.authorSilva, Pedro Morais
dc.contributor.authorFerraz, José
dc.contributor.authorMorête, Ana
dc.contributor.authorPinto, Claúdia Sofia
dc.contributor.authorSantos, Natacha
dc.contributor.authorLoureiro, Claúdia Chaves
dc.contributor.authorArrobas, Ana
dc.contributor.authorMarques, Maria Luís
dc.contributor.authorLozoya, Carlos
dc.contributor.authorLopes, Cristina
dc.contributor.authorCardia, Francisca
dc.contributor.authorLoureiro, Carla Chaves
dc.contributor.authorCâmara, Raquel
dc.contributor.authorVieira, Inês
dc.contributor.authorSilva, Sofia da
dc.contributor.authorSilva, Eurico
dc.contributor.authorRodrigues, Natalina
dc.contributor.authorFonseca, João A.
dc.date.accessioned2021-07-05T09:15:56Z
dc.date.available2021-07-05T09:15:56Z
dc.date.issued2021-01-24
dc.description.abstractWe aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13-17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.pt_PT
dc.description.sponsorshipThis research was funded by ERDF (European Regional Development Fund) through the operations: POCI-01-0145-36 FEDER-029130 (“mINSPIRE—mHealth to measure and improve adherence to medication in chronic respiratory diseases—generalisation and evaluation of gamification, peer support and advanced image processing technologies”) cofunded by the COMPETE2020 (Programa Operacional Competitividade e Internacionalização), Portugal 2020 and by Portuguese Funds through FCT (Fundação para a Ciência e a Tecnologia).pt_PT
dc.description.sponsorshipPOCI-01-0145-36 FEDER-029130
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAmaral, R.; Jácome, C.; Almeida, R.; Pereira, A.M.; Alves-Correia, M.; Mendes, S.; Rodrigues, J.C.C.; Carvalho, J.; Araújo, L.; Costa, A.; et al. Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies. Int. J. Environ. Res. Public Health 2021, 18, 1015. https://doi.org/10.3390/ijerph 18031015pt_PT
dc.identifier.doi10.3390/ijerph18031015pt_PT
dc.identifier.eissn1660-4601
dc.identifier.urihttp://hdl.handle.net/10400.26/36958
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/3/1015pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdolescentpt_PT
dc.subjectFemalept_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectPhenotypept_PT
dc.subjectPortugalpt_PT
dc.subjectProspective Studiespt_PT
dc.subjectSpainpt_PT
dc.subjectAsthmapt_PT
dc.titleProfiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage1015pt_PT
oaire.citation.titleInternational Journal of Environmental Research and Public Healthpt_PT
oaire.citation.volume18pt_PT
person.familyNameSilva Amaral
person.givenNameRita
person.identifierE-5535-2017
person.identifier.ciencia-id1A1E-751F-50F0
person.identifier.orcid0000-0002-0233-830X
person.identifier.scopus-author-id56067841600
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication63746e31-1ec0-4723-bfde-23f7a8a12b39
relation.isAuthorOfPublication.latestForDiscovery63746e31-1ec0-4723-bfde-23f7a8a12b39

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