Publication
Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients
| datacite.subject.fos | Ciências Médicas | |
| dc.contributor.author | Oliveira, Ana Maria; Oliveira, André; Vidal, Raquel; Gonçalves Pereira, João | |
| dc.date.accessioned | 2025-06-02T15:31:46Z | |
| dc.date.available | 2025-06-02T15:31:46Z | |
| dc.date.issued | 2024 | |
| dc.description.abstract | Abstract: Sepsis is among the most frequent diagnoses on admission to the intensive care unit (ICU). A systemic inflammatory response, activated by uncontrolled infection, fosters hypoperfusion and multiorgan failure and often leads to septic shock and mortality. These infections arise from a specific anatomic source, and how the infection foci influence the outcomes is unknown. All patients admitted to the ICU of Hospital de Vila Franca de Xira, between 1 January 2017 and 31 June 2023, were screened for sepsis and categorized according to their infection foci. During the study period, 1296 patients (32.2%) had sepsis on admission. Their mean age was 67.5 ± 15.3 and 58.1% were male; 73.0% had community-acquired infections. The lung was the main focus of infection. Septic shock was present in 37.9% of the patients and was associated with hospital mortality. Severe imbalances were noted in its incidence, and there was lower mortality in lung infections. The hospital-acquired infections had a slightly higher mortality but, after adjustment, this difference was non-significant. Patients with secondary bacteremia had a worse prognosis (one-year adjusted hazard ratio of 1.36, 95% confidence interval 1.06–1.74, p = 0.015), especially those with an isolated non-fermenting Gram negative infection. Lung, skin, and skin structure infections and peritonitis had a worse prognosis, whilst urinary, biliary tract, and other intra-abdominal infections had a better one-year outcome | por |
| dc.identifier.doi | 10.3390/microorganisms12081705 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/57923 | |
| dc.language.iso | eng | |
| dc.peerreviewed | yes | |
| dc.relation.hasversion | https://doi.org/ 10.3390/microorganisms12081705 | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
| dc.title | Infectious Foci, Comorbidities and Its Influence on the Outcomes of Septic Critically Ill Patients | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Microorganisms | |
| oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 |