Repository logo
 
Publication

Eligibility for Pre-exposure Prophylaxis According to Different Guidelines in a Cohort of HIV-Negative Men Who Have Sex with Men in Lisbon, Portugal

2020-01-03Journal article Restricted access
Simple item page
dc.contributor.authorMeireles, Paula
dc.contributor.authorPlankey, Michael
dc.contributor.authorRocha, Miguel
dc.contributor.authorRojas, Jesus
dc.contributor.authorBrito, João
dc.contributor.authorBarros, Henrique
dc.date.accessioned2024-06-17T16:10:49Z
dc.date.available2024-06-17T16:10:49Z
dc.date.issued2020-01-03
dc.date.updated2024-06-10T12:58:37Z
dc.description.abstractObjectives Defining eligibility for preexposure prophylaxis (PrEP) is key to measuring the degree of PrEP implementation. While the clinical exclusion criteria are identical across different guidelines, definitions of substantial HIV risk are not. In this study, we aimed to estimate the proportion of men who have sex with men (MSM) being tested at a community-based voluntary human immunodeficiency virus (HIV) counseling and testing center in Lisbon that would be eligible for PrEP according to guidelines from the World Health Organization (WHO), the US Public Health Service and Centers for Disease Control and Prevention (US-CDC), the European AIDS Clinical Society (EACS), and the Portuguese National Health Service (PNHS). Methods We used baseline data from 3392 HIV-negative MSM with valid information on eligibility for PrEP enrolled in the Portuguese Lisbon Cohort of MSM—an observational study designed as an open prospective, noninterval cohort—between March 2014 and March 2018. Results At baseline, the proportion of MSM eligible for PrEP was 67.7% according to the US-CDC, 60.6% according to the PNHS guidelines, 58.9% according to the WHO, and 46.5% according to the EACS guidelines. The most frequently met criteria were those related to condomless anal intercourse. Conclusions In conclusion, in the same population, the proportion of men eligible for PrEP differed by guideline, ranging from 46.5% to 67.7%, though if they all seem to include the same well-known predictors of HIV seroconversion. Policy implications These results show that both the allocation of resources and the approaches to individual risk prediction are highly dependent on the chosen guideline. Moving the focus from assessing risk to assessing whether PrEP is a suitable option for a given individual in a given moment of his life might help to overcome guidelines limitations and create more equitable access.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.authenticusidP-00R-K3K
dc.identifier.doi10.1007/s13178-019-00426-9pt_PT
dc.identifier.eid2-s2.0-85077464088
dc.identifier.issn1868-9884
dc.identifier.issn1553-6610
dc.identifier.slugcv-prod-1711382
dc.identifier.urihttp://hdl.handle.net/10400.26/51060
dc.identifier.wosWOS:000505343500001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationEpidemiology Research Unit - Institute of Public Health, University of Porto
dc.relationMost at risk populations for HIV – is there a role for PrEP in the preventive armamentarium
dc.subjectHIVpt_PT
dc.subjectPre-exposure prophylaxispt_PT
dc.subjectMen who have sex with menpt_PT
dc.subjectEligibility determinationpt_PT
dc.titleEligibility for Pre-exposure Prophylaxis According to Different Guidelines in a Cohort of HIV-Negative Men Who Have Sex with Men in Lisbon, Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpidemiology Research Unit - Institute of Public Health, University of Porto
oaire.awardTitleMost at risk populations for HIV – is there a role for PrEP in the preventive armamentarium
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04750%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F112867%2F2015/PT
oaire.citation.titleSexuality Research and Social Policypt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameRocha
person.givenNameMiguel
person.identifier999820
person.identifier.ciencia-id5F19-66C4-5F80
person.identifier.orcid0000-0003-1057-2419
person.identifier.ridAAL-7984-2020
person.identifier.scopus-author-id57204739884
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid5F19-66C4-5F80 | Luís Miguel Carvalho Rocha
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationf47c1e01-1192-4946-89a8-66594bb7364e
relation.isAuthorOfPublication.latestForDiscoveryf47c1e01-1192-4946-89a8-66594bb7364e
relation.isProjectOfPublicationbf0d2b5f-ce73-4e53-9bc2-7e82b137d9e2
relation.isProjectOfPublication7c35c200-d5e3-4f82-a094-e816d8c4b6e0
relation.isProjectOfPublication.latestForDiscoverybf0d2b5f-ce73-4e53-9bc2-7e82b137d9e2

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
10.1007_s13178-019-00426-9.pdf
Size:
359.76 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

GAT - Artigo Científico