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Development of synthetic light-chain antibodies as novel and potent HIV fusion inhibitors

2016-07Journal article Open access
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dc.contributor.authorCunha-Santos, Catarina
dc.contributor.authorFigueira, Tiago N.
dc.contributor.authorBorrego, Pedro
dc.contributor.authorOliveira, Soraia S.
dc.contributor.authorRocha, Cheila
dc.contributor.authorCouto, Andreia
dc.contributor.authorCantante, Cátia
dc.contributor.authorSantos- Costa, Quirina
dc.contributor.authorAzevedo-Pereira, José M.
dc.contributor.authorFontes, Carlos M. G. A.
dc.contributor.authorTaveira, Nuno
dc.contributor.authorAires-Da-Silva, Frederico
dc.contributor.authorCastanho, Miguel A. R. B.
dc.contributor.authorVeiga, Ana Salomé
dc.contributor.authorGonçalves, João
dc.date.accessioned2016-10-12T15:54:41Z
dc.date.available2017-08-01T00:30:11Z
dc.date.issued2016-07
dc.descriptionThis is a non-final version of an article published in final form in AIDS. 2016 Jul 17;30(11):1691-701.pt_PT
dc.description.abstract"Objective: To develop a novel and potent fusion inhibitor of HIV infection based on a rational strategy for synthetic antibody library construction. Design: The reduced molecular weight of single-domain antibodies (sdAbs) allows targeting of cryptic epitopes, the most conserved and critical ones in the context of HIV entry. Heavy-chain sdAbs from camelids are particularly suited for this type of epitope recognition because of the presence of long and flexible antigen-binding regions [complementary-determining regions (CDRs)]."pt_PT
dc.identifier.citationAIDS. 2016 Jul 17;30(11):1691-701. doi: 10.1097/QAD.0000000000001108.pt_PT
dc.identifier.doi0.1097/QAD.0000000000001108pt_PT
dc.identifier.issn1691-1701
dc.identifier.urihttp://hdl.handle.net/10400.26/15096
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwerpt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relation.publisherversionhttp://journals.lww.com/aidsonline/pages/articleviewer.aspx?year=2016&issue=07170&article=00004&type=abstractpt_PT
dc.subjectHIV fusion inhibitorpt_PT
dc.subjectHR1pt_PT
dc.subjectSingle-domain antibodypt_PT
dc.subjectSynthetic librarypt_PT
dc.subjectVariable light-chainpt_PT
dc.titleDevelopment of synthetic light-chain antibodies as novel and potent HIV fusion inhibitorspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/HIVERA%2F0002%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/VIH%2FSAU%2F0029%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F73838%2F2010/PT
oaire.citation.endPage1701pt_PT
oaire.citation.startPage1691pt_PT
oaire.citation.titleAIDSpt_PT
oaire.citation.volume30(11)pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isProjectOfPublicationc3b60260-41c1-4212-93cd-191d5b2e6133
relation.isProjectOfPublicatione63cde82-fa32-4aed-90e7-c9443427f2e1
relation.isProjectOfPublication762fe003-cbac-4b3d-9a94-6adedbfc58ea
relation.isProjectOfPublication.latestForDiscovery8df953c6-70d4-4ffc-a98f-e71c9057555c

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