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Topically Applied therapies for the treatment of skin disease : Past Present and Future

dc.contributor.authorBrown, M
dc.contributor.authorWilliams, A
dc.contributor.authorChilcott, RP
dc.contributor.authorBrady, B
dc.contributor.authorLenn, J
dc.contributor.authorEvans, C
dc.contributor.authorAllen, L
dc.contributor.authorMcAuley, WA
dc.contributor.authorBeebeejaun, M
dc.contributor.authorHaslinger, J
dc.contributor.authorBeuttel, C
dc.contributor.authorVieira, R
dc.contributor.authorGuidali, F
dc.contributor.authorMiranda, M
dc.date.accessioned2024-06-30T21:03:59Z
dc.date.available2024-06-30T21:03:59Z
dc.date.issued2024
dc.description.abstractThe purpose of this review is to summarize essential biological, pharmaceutical and clinical aspects in the field of topically applied medicines that may help scientists when trying to develop new topical medicines. After a brief history of topical drug delivery, a review of the structure and function of the skin, routes of drug absorption and their limitations is then provided. The most prevalent diseases and current topical treatment approaches are then detailed, the organization of which reflects the key disease categories of autoimmune and inflammatory, microbial infections, skin cancers and genetic skin diseases. The complexity of topical product development through to large scale manufacture along with recommended risk mitigation approaches is then highlighted. As such topical treatments are applied externally patient preferences along with the challenges they invoke are then described and finally the future of this field of drug delivery is discussed with the emphasis on areas that are more likely to yield significant improvements over the topical medicines in current use or would expand the range of medicines and diseases treatable by this route of administration. Significance Statement This review of the key aspects the skin, its associated diseases and current treatments along with the intricacies of topical formulation development should be helpful in making judicious decisions about the development of new or improved topical medicines. These aspects include the choices of the active ingredients, formulations, the target patient populations preferences and limitations and the future with regards to new skin diseases and topical medicine approaches.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1124/pharmrev.123.000549pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/51176
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectDoenças da Pele/tratamento farmacológicopt_PT
dc.subjectSkin Diseases/drug therapypt_PT
dc.titleTopically Applied therapies for the treatment of skin disease : Past Present and Futurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPagePharmacol Rev . 2024 Jun 24:PHARMREV-AR-2021-000549.pt_PT
oaire.citation.titlePharmacological Reviewspt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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