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Comparative measurement and quantitative risk assessment of alcohol consumption through wastewater-based epidemiology: an international study in 20 cities

2016-09Journal article Open access
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dc.contributor.authorRyu, Yeonsuk
dc.contributor.authorBarceló, Damià
dc.contributor.authorBarrone, Leon P.
dc.contributor.authorBijlsma, Lubertus
dc.contributor.authorCastiglioni, Sara
dc.contributor.authorDe Voogt, Pim
dc.contributor.authorEmke, Erik
dc.contributor.authorHernández, Félix
dc.contributor.authorLai, Foon Yin
dc.contributor.authorLopes, Álvaro
dc.contributor.authorLópez de Alda, Miren
dc.contributor.authorMastroianni, Nicola
dc.contributor.authorMunro, Kelly
dc.contributor.authorO'Brien, Jake
dc.contributor.authorOrt, Christoph
dc.contributor.authorPlósz, Benedek G.
dc.contributor.authorReid, Malcolm J.
dc.contributor.authorYargeau, Viviane
dc.contributor.authorThomas, Kevin V.
dc.date.accessioned2017-11-16T11:07:34Z
dc.date.available2017-11-16T11:07:34Z
dc.date.issued2016-09
dc.descriptionThis work is licensed under a CC-BY licence - https://creativecommons.org/licenses/by/4.0/pt_PT
dc.description.abstractQuantitative measurement of drug consumption biomarkers in wastewater can provide objective information on community drug use patterns and trends. This study presents the measurement of alcohol consumption in 20 cities across 11 countries through the use of wastewater-based epidemiology (WBE), and reports the application of these data for the risk assessment of alcohol on a population scale using the margin of exposure (MOE) approach. Raw 24-h composite wastewater samples were collected over a one-week period from 20 cities following a common protocol. For each sample a specific and stable alcohol consumption biomarker, ethyl sulfate (EtS) was determined by liquid chromatography coupled to tandem mass spectrometry. The EtS concentrations were used for estimation of per capita alcohol consumption in each city, which was further compared with international reports and applied for risk assessment by MOE. The average per capita consumption in 20 cities ranged between 6.4 and 44.3 L/day/1000 inhabitants. An increase in alcohol consumption during the weekend occurred in all cities, however the level of this increase was found to differ. In contrast to conventional data (sales statistics and interviews), WBE revealed geographical differences in the level and pattern of actual alcohol consumption at an inter-city level. All the sampled cities were in the “high risk” category (MOE < 10) and the average MOE for the whole population studied was 2.5. These results allowed direct comparisons of alcohol consumption levels, patterns and risks among the cities. This study shows that WBE can provide timely and complementary information on alcohol use and alcohol associated risks in terms of exposure at the community level.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationScience of the Total Environment 565 (2016) 977–983. DOI 10.1016/j.scitotenv.2016.04.138pt_PT
dc.identifier.doi10.1016/j.scitotenv.2016.04.138pt_PT
dc.identifier.issn0048-9697
dc.identifier.urihttp://hdl.handle.net/10400.26/19341
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://doi.org/10.1016/j.scitotenv.2016.04.138pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectWastewaterpt_PT
dc.subjectDrug epidemiologypt_PT
dc.subjectBiomarker analysispt_PT
dc.subjectAlcoholpt_PT
dc.subjectEthyl sulfatept_PT
dc.subjectMargin of exposurept_PT
dc.titleComparative measurement and quantitative risk assessment of alcohol consumption through wastewater-based epidemiology: an international study in 20 citiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage983pt_PT
oaire.citation.startPage977pt_PT
oaire.citation.titleScience of The Total Environmentpt_PT
oaire.citation.volume565pt_PT
person.familyNamede Voogt
person.givenNamePim
person.identifier.orcid0000-0001-9065-9797
person.identifier.ridC-5683-2017
person.identifier.scopus-author-id7003271208
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4f174313-6bb4-49ed-984b-2ee9958c0f93
relation.isAuthorOfPublication.latestForDiscovery4f174313-6bb4-49ed-984b-2ee9958c0f93

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