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The role of immune checkpoint blockade in acute myeloid leukemia

2022-07-11Journal article Open access
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dc.contributor.authorSilva, Margarida
dc.contributor.authorMartins, Diana
dc.contributor.authorMendes, Fernando
dc.date.accessioned2022-10-11T13:31:03Z
dc.date.available2022-10-11T13:31:03Z
dc.date.issued2022-07-11
dc.description.abstractImmune checkpoint inhibition (ICI) has emerged as a therapeutic option for acute myeloid leukemia (AML) for patients that suffer from relapsed or high-risk disease, or patients ineligible for standard therapy. We aimed to study ICI as monotherapy and/or combined therapy (with chemotherapy (QT), for AML patients. The PRISMA statement was used. The literature used comprised clinical trials, randomized controlled trials, and systematic reviews published within the last 7 years. The blockade of CTLA-4 presented a 42% of complete remission within AML. Nivolumab in high-risk AML showed a median recurrence-free survival (RFS) of 8.48 months. The same drug on relapsed hematologic malignancies after allogenic transplantation shows a 1-year OS of 56%. The use of prophylaxis post allogenic transplantation cyclophosphamide (PTCy), following checkpoint inhibition, demonstrated different baseline disease and transplantation characteristics when compared to no-PCTy patients, being 32% and 10%, respectively. CTLA-4 blockage was a worthy therapeutic approach in relapsed hematologic malignancies, presenting long-lasting responses. The approach to AML and myelodysplastic syndrome patients with ICI before allogenic hematopoietic stem cell transplantation and the use of a graft-versus-host disease prophylaxis have shown improvement in the transplantation outcomes, and therefore AML treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, M.; Martins, D.; Mendes, F. The role of immune checkpoint blockade in acute myeloid leukemia. Onco 2022, 2, 164-180. https://doi.org/10.3390/onco2030011pt_PT
dc.identifier.doi10.3390/onco2030011pt_PT
dc.identifier.issn2673-7523
dc.identifier.urihttp://hdl.handle.net/10400.26/41902
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCenter for Innovative Biomedicine and Biotechnology
dc.relationCNC. IBILI
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/pt_PT
dc.subjectAcute myeloid leukemiapt_PT
dc.subjectTreatmentpt_PT
dc.subjectImmune checkpointpt_PT
dc.subjectLeucemia mieloide agudapt_PT
dc.subjectTerapêuticapt_PT
dc.subjectInibidores de checkpoint imunológicopt_PT
dc.titleThe role of immune checkpoint blockade in acute myeloid leukemiapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCenter for Innovative Biomedicine and Biotechnology
oaire.awardTitleCNC. IBILI
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04539%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FNEU%2F04539%2F2019/PT
oaire.citation.conferencePlaceBasileia, Suíçapt_PT
oaire.citation.endPage180pt_PT
oaire.citation.startPage164pt_PT
oaire.citation.titleOncopt_PT
oaire.citation.volume2pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMartins
person.familyNameMendes
person.givenNameDiana
person.givenNameFernando
person.identifier.ciencia-id411F-DB62-27F7
person.identifier.ciencia-id6B14-CDEA-CCAE
person.identifier.orcid0000-0002-1457-8992
person.identifier.orcid0000-0002-5205-8939
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication27a35546-e9fe-4fbf-a943-781a7b0cf24d
relation.isAuthorOfPublication80fd11cb-dd17-4836-a2b6-39a0b67b4663
relation.isAuthorOfPublication.latestForDiscovery27a35546-e9fe-4fbf-a943-781a7b0cf24d
relation.isProjectOfPublication381219d9-d6f1-4538-b2e2-6cec7ec21210
relation.isProjectOfPublicationd37cf492-b9e1-451e-b420-d368ba277548
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