Entry inhibitors and Carbosilane dendrimers are potent inhibitors of cell-associated HIV-2 infection

Diniz, A. R.; Briz, V.; Borrego, P.; Palladino, C.; Rodés, C.; De la Mata, F. J.; Gómez, R.; Muñoz-Fernández, M. A.; Taveira, N.

http://hdl.handle.net/10400.26/15088

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Autores

Muñoz-Fernández, M. A.

Taveira, N.

Resumo(s)

"Pre-exposure prophylaxis with topical microbicides formulated with antiviral agents can prevent HIV-1 acquisition. The ideal microbicide should prevent both cell-free and cell-associated HIV-1 and HIV-2 infections in the vaginal or rectum mucosa. So far, few candidate microbicides have been tested against HIV-2. Previously, we have shown that anionic carbosilane dendrimers 2G-S16 (sulphonate), G2-NF16 (naphthylsulfonated) and G3-S16 (sulphated-end groups) have potent antiviral activity against HIV-1. In this work, we evaluated the activity of these dendrimers and the fusion inhibitors T-1249 and T20 in preventing cell-free and cellassociated HIV-2 infection."