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Single application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis : A split-mouth, randomized, controlled pilot clinical trial

2019-11Journal article Restricted access
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dc.contributor.authorLobato, Joana Cristina Rico Farto
dc.contributor.authorVilhena, Mafalda Alexandra dos Santos
dc.contributor.authorIzidoro, Catarina
dc.contributor.authorAlves, Ricardo Castro
dc.contributor.authorProença, Luís
dc.date.accessioned2020-10-20T15:57:45Z
dc.date.available2020-10-20T15:57:45Z
dc.date.issued2019-11
dc.description.abstractBackground: Topical coadjuvants might be indicated to increase the results of nonsurgical periodontal treatment and overcome some of its limitations. The aim of this study was to evaluate the clinical benefits of a single topical application of 0.8% hyaluronic acid (HA) as a coadjuvant to scaling and root planing (SRP) in periodontal patients. Materials and Methods: Sixteen patients diagnosed with periodontitis were recruited to participate in this split-mouth randomized controlled trial. At baseline, oral hygiene instructions, prophylaxis, and SRP were performed in both sides; additionally, a subgingival application of HA at 0.8% was made in the test side. Several clinical parameters were assessed at baseline, 6, and 12 weeks later: full mouth plaque score, gingival score, bleeding on probing (BoP), probing depth (PD), and clinical attachment level (CAL). Results: At the end of 12 weeks, there was a overall improvement in all periodontal parameters in both sides (P < 0.05). Test sides showed less BoP when compared to the control sides (9.4 ± 4.0 vs. 14.9 ± 8.9, P < 0.05). Other periodontal parameters such as PD and CAL showed a slight improvement in comparison with the control sides, but the difference was not statistically significant (P > 0.05). Conclusion: Results from this study indicate that a single subgingival application of 0.8% HA seems to reduce gingival inflammation and improve clinical parameters, particularly BoP. Further studies are needed to evaluate the effect of repeated application of HA and long-term results.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLobato JC, Santos Vilhena MA, Izidoro C, Alves RC, Proença L. Single application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis: A split-mouth, randomized, controlled pilot clinical trial. J Indian Soc Periodontol 2019;23:545-8pt_PT
dc.identifier.doi10.4103/jisp.jisp_674_18pt_PT
dc.identifier.issn0972-124X
dc.identifier.issn0975-1580
dc.identifier.urihttp://hdl.handle.net/10400.26/33686
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWolters Kluwer : Medknowpt_PT
dc.relation.publisherversionhttps://www.jisponline.com/text.asp?2019/23/6/545/271838pt_PT
dc.subjectHyaluronic acidpt_PT
dc.subjectNonsurgical periodontal treatmentpt_PT
dc.subjectPeriodontitispt_PT
dc.subjectScaling and root planningpt_PT
dc.titleSingle application of 0.8% hyaluronic acid as a coadjuvant of nonsurgical treatment in nonsmoking patients with periodontitis : A split-mouth, randomized, controlled pilot clinical trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage548pt_PT
oaire.citation.startPage545pt_PT
oaire.citation.titleJournal of Indian Society of Periodontologypt_PT
oaire.citation.volume23(6)pt_PT
rcaap.embargofctPolítica de copyright do editorpt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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