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Azathioprine-induced interstitial nephritis in an anti-neutrophil cytoplasmic antibody (ANCA) myeloperoxidase (MPO) vasculitis patient

2018Journal article Open access
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dc.contributor.authorPires da Rosa, Gilberto
dc.contributor.authorMarques, Sofia
dc.contributor.authorCoelho, Fátima
dc.contributor.authorPereira, Edite
dc.contributor.authorFerreira, Ester
dc.contributor.authorRodrigues-Pereira, Pedro
dc.contributor.authorDias, Dias
dc.contributor.authorBettencourt, Paulo
dc.date.accessioned2018-11-28T01:06:06Z
dc.date.available2018-11-28T01:06:06Z
dc.date.issued2018
dc.description.abstractAzathioprine (AZA) is used in a wide array of autoimmune diseases, still corresponding to the mainstay maintenance therapy in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides. Although generally well-tolerated, several side effects are recognized. We report the case of a 50-year-old Caucasian man with kidney-limited ANCA myeloperoxidase (MPO) vasculitis who presented with general malaise, fever, worsening renal function, and elevated inflammatory markers 2 weeks after the initiation of therapy with oral AZA. Although a disease relapse was suspected, renal biopsy revealed an eosinophilic infiltrate, suggestive of acute interstitial nephritis. After suspension of AZA, a sustained improvement of renal function and normalization of inflammatory markers was observed. A diagnosis of allergic interstitial nephritis secondary to AZA was established, corresponding to the first biopsy-proven case described in an ANCA MPO vasculitis patient. Although rare, renal toxicity of AZA must be present in the clinician's mind, avoiding the straightforward assumption of disease relapse in the case of worsening renal function.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAzathioprineinduced interstitial nephritis in an antineutrophil cytoplasmic antibody (ANCA) myeloperoxidase (MPO) vasculitis patient. Eur J Rheumatol 2018; 5: 135-8pt_PT
dc.identifier.doi10.5152/eurjrheum.2017.17062pt_PT
dc.identifier.issn2147-9720
dc.identifier.urihttp://hdl.handle.net/10400.26/25052
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAVESpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAzathioprinept_PT
dc.subjectinterstitial nephritispt_PT
dc.subjectANCApt_PT
dc.subjectvasculitispt_PT
dc.titleAzathioprine-induced interstitial nephritis in an anti-neutrophil cytoplasmic antibody (ANCA) myeloperoxidase (MPO) vasculitis patientpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage138pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage135pt_PT
oaire.citation.titleEuropean Journal of Rheumatologypt_PT
oaire.citation.volume5pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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