Publication
The prognostic impact of magnesium in acute heart failure is different according to the presence of diabetes mellitus
| dc.contributor.author | Cidade-Rodrigues, C | |
| dc.contributor.author | Cunha, FM | |
| dc.contributor.author | Elias, C | |
| dc.contributor.author | Carreira, M | |
| dc.contributor.author | Barroso, I | |
| dc.contributor.author | Bettencourt, P | |
| dc.contributor.author | Lourenço, P | |
| dc.date.accessioned | 2023-05-22T11:10:52Z | |
| dc.date.available | 2023-05-22T11:10:52Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Hypermagnesemia predicts mortality in chronic heart failure (HF); however, in acute HF, magnesium does not seem to be outcome-associated. Diabetes mellitus (DM) frequently associates with altered magnesium status. We hypothesized that DM might influence the prognostic impact of magnesium in acute HF. Methods: This is a retrospective cohort study of hospitalized patients with acute HF. Patients without data on admission serum magnesium were excluded. Follow-up: 1 year from hospital admission. Primary end point: all-cause mortality. Patients were divided according to median serum magnesium (1.64 mEq/L). The Kaplan-Meier survival method was used to determine survival curves according to magnesium levels. The analysis was stratified according to the presence of DM. A multivariable Cox regression analysis was used to study the prognostic impact of magnesium. Results: We studied 606 patients. The mean age was 76 ± 12 years, 44.1% were male, 50.7% had DM, and 232 (38.3%) died during follow-up. Median magnesium was 1.64 (1.48-1.79) mEq/L. Patients with magnesium ≥1.64 mEq/L had higher 1-year mortality [141 (46.4%) vs 91 (30.1%), P < .001]. After adjustments for age, sex, history of atrial fibrillation, systolic blood pressure, heart rate, ischemic etiology, B-type natriuretic peptide, estimated glomerular filtration rate, alcohol consumption, antihyperglycaemic agents or glycated hemoglobin, admission glycemia, New York Heart Association class IV, and severe left ventricle systolic dysfunction, serum magnesium ≥1.64 mEq/L was associated with higher mortality only in patients with DM: HR 1.89 (95% confidence interval: 1.19-3.00), P = .007, and 1.27 (95% confidence interval: 0.83-1.94) and P = .26 for non-DM patients. The results were similar if magnesium was analyzed as a continuous variable. Per 0.1 mEq/L increase in magnesium levels, patients with DM had 13% increased risk of 1-year mortality. Conclusions: Higher magnesium levels were associated with worse prognosis only in HF patients with DM. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Porto Biomed J . 2022 Dec 1;7(6):e197. | pt_PT |
| dc.identifier.doi | 10.1097/j.pbj.0000000000000197 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/44837 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Diabetes Mellitus | pt_PT |
| dc.subject | Insuficiência Cardíaca | pt_PT |
| dc.subject | Magnésio | pt_PT |
| dc.subject | Heart Failure | pt_PT |
| dc.subject | Magnesium | pt_PT |
| dc.title | The prognostic impact of magnesium in acute heart failure is different according to the presence of diabetes mellitus | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 6 | pt_PT |
| oaire.citation.startPage | e197 | pt_PT |
| oaire.citation.title | Porto Biomedical Journal | pt_PT |
| oaire.citation.volume | 7 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |