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Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medical Use Purchased in Portugal

2024Journal article Open access
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dc.contributor.authorPires, Bruno
dc.contributor.authorOliveira, Patrik
dc.contributor.authorSimão, Ana Y.
dc.contributor.authorReis, João
dc.contributor.authorRamos, Sofia
dc.contributor.authorDuarte, Ana Paula
dc.contributor.authorMargalho, Cláudia
dc.contributor.authorRosado, Tiago
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2024-08-08T09:18:49Z
dc.date.available2024-08-08T09:18:49Z
dc.date.issued2024
dc.description.abstractCannabis-based products have gained attention in recent years for their perceived therapeutic benefits (with cannabinoids such as THC and CBD) and widespread availability. However, these products often lack accurate labelling regarding their cannabinoid content. Our study, conducted with products available in Portugal, revealed significant discrepancies between label claims and actual cannabinoid compositions. A fully validated method was developed for the characterisation of different products acquired from pharmacies and street shops (beverages, herbal samples, oils, and cosmetic products) using high-performance liquid chromatography coupled with a diode array detector. Linearity ranged from 0.4 to 100 µg/mL (0.04–10 µg/mg) (THC, 8-THC, CBD, CBG, CBDA, CBGA), 0.1–100 µg/mL (0.01–10 µg/mg) (CBN), 0.4–250 µg/mL (0.04–25 µg/mg) (THCA-A), and 0.8–100 µg/mL (0.08–10 µg/mg) (CBCA). Among sampled beverages, none contained detectable cannabinoids, despite suggestive packaging. Similarly, oils often differed from the declared cannabinoid compositions, with some containing significantly higher CBD concentrations than labelled. These inconsistencies raise serious concerns regarding consumer safety and informed decision-making. Moreover, our findings underscore the need for stringent regulation and standardised testing protocols to ensure the accuracy and safety of cannabis-based products.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPires, B., Oliveira, P., Simão, A. Y., Reis, J., Ramos, S., Duarte, A. P., Margalho, C., Rosado, T., Barroso, M., & Gallardo, E. (2024). Characterisation of Cannabis-Based Products Marketed for Medical and Non-Medical Use Purchased in Portugal. Molecules (Basel, Switzerland), 29(12), 2737pt_PT
dc.identifier.doi10.3390/molecules29122737pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/51594
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCannabispt_PT
dc.subjectTHCpt_PT
dc.subjectCannabidiolpt_PT
dc.subjectMarket productspt_PT
dc.subjectPortugalpt_PT
dc.titleCharacterisation of Cannabis-Based Products Marketed for Medical and Non-Medical Use Purchased in Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2020.09070.BD/PT
oaire.citation.issue12pt_PT
oaire.citation.startPage2737pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume29pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameMargalho
person.familyNameBarroso
person.givenNameCláudia
person.givenNameMário
person.identifier.ciencia-idA211-521D-90CA
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0003-1661-0367
person.identifier.orcid0000-0001-8848-2734
person.identifier.ridKII-2916-2024
person.identifier.scopus-author-id8655072100
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
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