A carregar...
Publicação
Prevalência e associação bidirecional entre diabetes mellitus e periodontite : uma revisão sistemática
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 2.04 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Objetivos: Estimar a prevalência de periodontite em indivíduos com diabetes mellitus tipo 2 (DM2) e a prevalência de DM2 em indivíduos com periodontite através de duas meta-análises de prevalência.
Materiais e Métodos: Foram pesquisados estudos observacionais publicados entre 2000 e 2025 nas bases de dados PubMed, Embase, Scopus, Cochrane Library e Google Scholar. Foram incluídos estudos em adultos com diagnóstico confirmado de DM2 através de critérios laboratoriais e diagnóstico clínico de periodontite,
independentemente da definição periodontal utilizada nos estudos originais. As prevalências combinadas foram estimadas através de modelos de efeitos aleatórios com transformação logit. Meta-regressão foi realizada para explorar o efeito do sexo, e viés de publicação foi avaliado através do teste de Egger.
Resultados: Foram incluídos 22 estudos únicos, correspondendo a 23 entradas analíticas (n = 9758 participantes): 16 estudos (n = 4608) para prevalência de periodontite em DM2 e 7 estudos (n = 5150) para prevalência de DM2 em periodontite. A prevalência combinada de periodontite em indivíduos com DM2 foi de 78,9% (IC 95%: 63,6%–88,9%; I² = 98,2%), enquanto a prevalência de DM2 em indivíduos com periodontite foi de 16,1% (IC 95%: 6,3%–35,3%; I² = 99,3%). A metaregressão não revelou efeito significativo do sexo (β = -2,16; p = 0,072). O teste de Egger evidenciou assimetria significativa (p = 0,034), sugerindo possível viés de publicação ou small-study effects, embora a interpretação seja limitada pela heterogeneidade extrema.
Conclusão: Os resultados sugerem uma coexistência frequente entre DM2 e periodontite em diferentes contextos clínicos e populacionais. A padronização dos critérios diagnósticos e o desenvolvimento de estudos epidemiológicos mais homogéneos poderão contribuir para uma melhor compreensão da relação bidirecional entre ambas as condições.
Objectives: To estimate the prevalence of periodontitis in individuals with type 2 diabetes mellitus (T2DM) and the prevalence of T2DM in individuals with periodontitis through two prevalence meta-analyses. Materials and Methods: Observational studies published between 2000 and 2025 were searched in the PubMed, Embase, Scopus, Cochrane Library, and Google Scholar databases. Studies including adults with laboratory-confirmed T2DM and clinically diagnosed periodontitis were included, regardless of the periodontal definition used in the original studies. Pooled prevalence estimates were calculated using random-effects models with logit transformation. Meta-regression was performed to explore the effect of sex, and publication bias was assessed using Egger’s test. Results: Twenty-two unique studies, corresponding to 23 analytical entries, were included (n = 9758 participants): 16 studies (n = 4608) assessed the prevalence of periodontitis in individuals with T2DM and 7 studies (n = 5150) assessed the prevalence of T2DM in individuals with periodontitis. The pooled prevalence of periodontitis in individuals with T2DM was 78,9% (95% CI: 63,6%–88,9%; I² = 98,2%), whereas the pooled prevalence of T2DM in individuals with periodontitis was 16,1% (95% CI: 6,3%–35,3%; I² = 99,3%). Meta-regression did not reveal a significant effect of sex (β = -2,16; p = 0,072). Egger’s test showed significant asymmetry (p = 0,034), suggesting possible publication bias or small-study effects, although interpretation was limited by the extreme heterogeneity. Conclusion: The results suggest a frequent coexistence between T2DM and periodontitis across different clinical and population settings. Standardization of diagnostic criteria and the development of more homogeneous epidemiological studies may contribute to a better understanding of the bidirectional relationship between both conditions.
Objectives: To estimate the prevalence of periodontitis in individuals with type 2 diabetes mellitus (T2DM) and the prevalence of T2DM in individuals with periodontitis through two prevalence meta-analyses. Materials and Methods: Observational studies published between 2000 and 2025 were searched in the PubMed, Embase, Scopus, Cochrane Library, and Google Scholar databases. Studies including adults with laboratory-confirmed T2DM and clinically diagnosed periodontitis were included, regardless of the periodontal definition used in the original studies. Pooled prevalence estimates were calculated using random-effects models with logit transformation. Meta-regression was performed to explore the effect of sex, and publication bias was assessed using Egger’s test. Results: Twenty-two unique studies, corresponding to 23 analytical entries, were included (n = 9758 participants): 16 studies (n = 4608) assessed the prevalence of periodontitis in individuals with T2DM and 7 studies (n = 5150) assessed the prevalence of T2DM in individuals with periodontitis. The pooled prevalence of periodontitis in individuals with T2DM was 78,9% (95% CI: 63,6%–88,9%; I² = 98,2%), whereas the pooled prevalence of T2DM in individuals with periodontitis was 16,1% (95% CI: 6,3%–35,3%; I² = 99,3%). Meta-regression did not reveal a significant effect of sex (β = -2,16; p = 0,072). Egger’s test showed significant asymmetry (p = 0,034), suggesting possible publication bias or small-study effects, although interpretation was limited by the extreme heterogeneity. Conclusion: The results suggest a frequent coexistence between T2DM and periodontitis across different clinical and population settings. Standardization of diagnostic criteria and the development of more homogeneous epidemiological studies may contribute to a better understanding of the bidirectional relationship between both conditions.
Descrição
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Palavras-chave
Diabetes mellitus tipo 2 Periodontite Prevalência Revisão sistemática