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Olanzapine: challenges in toxicological results interpretation

2017-09Other Open access
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dc.contributor.authorCosta Lopes, Miguel
dc.contributor.authorAbreu, Ana
dc.contributor.authorNascimento, João
dc.contributor.authorSardinha, Mário
dc.contributor.authorCastañera, Antonio
dc.contributor.authorFonseca, Suzana
dc.contributor.authorFranco, João
dc.contributor.authorNikolić, Dobrila
dc.date.accessioned2022-12-19T11:30:00Z
dc.date.available2022-12-19T11:30:00Z
dc.date.issued2017-09
dc.descriptionApresentação Oral realizada na Forensic Medicine Conference of the Baltic Medico-Legal Association, 20th - 22nd of September 2017, Tallinn, Estoniapt_PT
dc.description.abstractFatal intoxications are a topic of great relevance in today's society and a massive challenge for pathologists all over the world. In post-mortem investigations it is often challenging to determine if and which drug(s) caused the death due to the post-mortem processes in a body. This study evaluates forensic fatal cases with positive blood levels for the antipsychotic Olanzapine. The aim of this study is to characterize the sample of such forensic autopsy cases and try to correlate the Olanzapine concentrations with the manner of death and cause of death attributed in the reports. We performed a retrospective, observational and descriptive study, analyzing the reports of forensic autopsies performed in the South Branch of the National Institute of Legal Medicine and Forensic Sciences, in Lisbon, Portugal, from 2013 until 2015. A total of 53 forensic autopsy cases characterized by the presence of Olanzapine were analyzed. Blood Olanzapine concentrations ranged from 10ng/ml to 4363ng/ml. The following variables were collected: sex, age, place of death, number of days between death and autopsy, clinical history, signals of putrefaction, cause of death, manner of death and ancillary tests performed, such as toxicological and histological exams. This study raises the need of awareness for the most common limitations that forensic pathologists face in the interpretation of toxicological results and indicate the need to create a reference table for each substance with our casuistic.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/42688
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectFatal intoxicationspt_PT
dc.subjectOlanzapinept_PT
dc.titleOlanzapine: challenges in toxicological results interpretationpt_PT
dc.typeother
dspace.entity.typePublication
oaire.citation.conferencePlaceTallinn (Estonia)pt_PT
oaire.citation.titleForensic Medicine Conference of the Baltic Medico-Legal Associationpt_PT
person.familyNameCosta Lopes
person.familyNameSardinha
person.familyNameCastañera
person.familyNameFonseca
person.givenNameMiguel
person.givenNameMário
person.givenNameAntonio
person.givenNameSuzana
person.identifier.ciencia-id991E-D783-2FC0
person.identifier.ciencia-idC31D-C5F1-D6BD
person.identifier.orcid0000-0002-7637-6755
person.identifier.orcid0000-0003-1800-7182
person.identifier.orcid0000-0002-3017-8569
person.identifier.orcid0000-0001-9122-1017
rcaap.rightsopenAccesspt_PT
rcaap.typeotherpt_PT
relation.isAuthorOfPublication5f72f0ca-156f-4181-a487-c358663e0100
relation.isAuthorOfPublicationbaceb807-d4f7-4083-9220-41180b94a3fb
relation.isAuthorOfPublicationd3578c9c-8367-4088-8551-6b9020896ef7
relation.isAuthorOfPublicationbee010fc-708e-4a25-9dad-ddf0b1d56c17
relation.isAuthorOfPublication.latestForDiscoveryd3578c9c-8367-4088-8551-6b9020896ef7

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