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Characterization of Antidepressant Consumption in a Portuguese Inland Population.

2025-08-31Artigo científico Acesso aberto
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dc.contributor.authorSoares, Sofia
dc.contributor.authorRosado, Tiago
dc.contributor.authorSantos, Vítor Hugo
dc.contributor.authorRei, Cristina
dc.contributor.authorAmantegui, Patricia
dc.contributor.authorPissarra da Costa, António
dc.contributor.authorChaves, Telma
dc.contributor.authorValente, Rita
dc.contributor.authorDuarte, Fábio
dc.contributor.authorPacheco, Susana
dc.contributor.authorMartins, Marco
dc.contributor.authorDias, Kátia
dc.contributor.authorCosta, Patricia
dc.contributor.authorCosta, Rui
dc.contributor.authorCastro, Sílvia
dc.contributor.authorSousa, Diana
dc.contributor.authorFigueiredo, Diana
dc.contributor.authorSoares, Isabel
dc.contributor.authorMouta, Salomé
dc.contributor.authorJesus, Bianca
dc.contributor.authorPires, Ana
dc.contributor.authorRibeiro, Cândida
dc.contributor.authorLobo, Sónia
dc.contributor.authorCorreia, Leonor
dc.contributor.authorMalés, Sofia
dc.contributor.authorVale, Fátima
dc.contributor.authorMoita, Carina
dc.contributor.authorMoura, Carolina
dc.contributor.authorSousa, Joana
dc.contributor.authorAfonso, Luís Rafael
dc.contributor.authorCosta, Rita Santinho
dc.contributor.authorBarroso, Mário
dc.contributor.authorGallardo, Eugenia
dc.date.accessioned2026-01-29T17:27:07Z
dc.date.available2026-01-29T17:27:07Z
dc.date.issued2025-08-31
dc.description.abstractMental disorders are a growing global concern, with depression being among the most prevalent. Portugal ranks second in antidepressant consumption within the OECD, following a threefold increase between 2000 and 2020. In inland regions such as Beira Interior, reduced healthcare services and distance from major hospitals further complicate access to care. This study analysed 142 patients from Beira Interior undergoing antidepressant therapy to characterise their demographic and clinical profile and to assess associations with adverse effects. A cross-sectional survey collected demographic data, clinical diagnoses, prescribed antidepressants, concomitant medications, and reported adverse effects. Both descriptive and inferential statistical analyses were performed. Most participants were female (81.0%), with a mean age of 57.8 years. Major depression was the most common diagnosis (76.1%). Selective serotonin reuptake inhibitors (47.4%) and trazodone (27.8%) were the most prescribed agents. Treatment had lasted one to five years in 59.9% of cases. Concomitant use of benzodiazepines (76.8%) and antipsychotics (48.6%) was frequent. Reported adverse effects included anticholinergic symptoms (38.7%) and confusion/agitation (26.8%). Women were more likely to use serotonin modulators, while patients >64 years had higher odds of using tetracyclic/unicyclic antidepressants, serotonin modulators, and multiple antidepressants. These classes were significantly associated with increased adverse effects. The findings reveal important risks related to polypragmasia and adverse reactions, underscoring the need for individualised prescribing, rigorous monitoring, and strict adherence to guidelines. Larger, stratified, and longitudinal studies are needed to clarify causality and optimise treatment outcomes.eng
dc.identifier.citationSoares, S., Rosado, T., Santos, V. H., Rei, C., Amantegui, P., Pissarra da Costa, A., Chaves, T., Valente, R., Duarte, F., Pacheco, S., Martins, M., Dias, K., Costa, P., Costa, R., Castro, S., Sousa, D., Figueiredo, D., Soares, I., Mouta, S., Jesus, B., … Gallardo, E. (2025). Characterization of Antidepressant Consumption in a Portuguese Inland Population. Healthcare (Basel, Switzerland), 13(17), 2177.
dc.identifier.doi10.3390/healthcare13172177
dc.identifier.issn2227-9032
dc.identifier.urihttp://hdl.handle.net/10400.26/61313
dc.language.isoen
dc.peerreviewedyes
dc.publisherMDPI
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectPortuguese population
dc.subjectantidepressants consumption
dc.subjectcharacterization
dc.subjectstatistical data
dc.subjectsurveys
dc.titleCharacterization of Antidepressant Consumption in a Portuguese Inland Population.eng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberUIDB/00709/2020
oaire.awardNumberUIDP/00709/2020
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00709%2F2020/PT
oaire.citation.titleHealthcare (Basel, Switzerland)
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBarroso
person.givenNameMário
person.identifier.ciencia-id5110-F476-ECCC
person.identifier.orcid0000-0001-8848-2734
person.identifier.scopus-author-id35329243100
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication294b555e-48c4-4013-b981-b8917400c56c
relation.isAuthorOfPublication.latestForDiscovery294b555e-48c4-4013-b981-b8917400c56c
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relation.isProjectOfPublication56ce2e5c-35e5-4eb7-8152-2e87e77f638c
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