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Emergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acid

2013Journal article Open access
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dc.contributor.authorMascarenhas-Melo, Filipa
dc.contributor.authorPalavra, Filipe
dc.contributor.authorMarado, Daniela
dc.contributor.authorSereno, José
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorFreitas, Isabel
dc.contributor.authorMendonça, Maria Isabel
dc.contributor.authorPinto, Rui
dc.contributor.authorTeixeira, Frederico
dc.contributor.authorF, Reis
dc.date.accessioned2019-03-06T11:39:18Z
dc.date.available2019-03-06T11:39:18Z
dc.date.issued2013
dc.description.abstractThis study intended to determine the impact of HDL-c and/or TGs levels on patients with average LDL-c concentration, focusing on lipidic, oxidative, inflammatory, and angiogenic profiles. Patients with cardiovascular risk factors (n = 169) were divided into 4 subgroups, combining normal and low HDL-c with normal and high TGs patients. The following data was analyzed: BP, BMI, waist circumference and serum glucose, Total-c, TGs, LDL-c, oxidized-LDL, total HDL-c and HDL subpopulations, paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF- α , adiponectin, VEGF, and iCAM1. The two populations with increased TGs levels, regardless of the normal or low HDL-c, presented obesity and higher waist circumference, Total-c, LDL-c, Ox-LDL, and uric acid. Adiponectin concentration was significantly lower and VEGF was higher in the population with cumulative low values of HDL-c and high values of TGs, while HDL quality was reduced in the populations with impaired values of HDL-c and/or TGs, viewed by reduced large and increased small HDL subfractions. In conclusion, in a population with cardiovascular risk factors, low HDL-c and/or high TGs concentrations seem to be associated with a poor cardiometabolic profile, despite average LDL-c levels. This condition, often called residual risk, is better evidenced by using both traditional and nontraditional CV biomarkers, including large and small HDL subfractions, Ox-LDL, adiponectin, VEGF, and uric acid.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMascarenhas-Melo, F., Palavra, F., Marado, D., Sereno, J., Teixeira-Lemos, E., Freitas, I., ... & Reis, F. (2013). Emergent biomarkers of residual cardiovascular risk in patients with low HDL-c and/or high triglycerides and average LDL-c concentrations: focus on HDL subpopulations, oxidized LDL, adiponectin, and uric acid. The Scientific World Journal, 2013.pt_PT
dc.identifier.doi10.1155/2013/387849pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/28010
dc.language.isoengpt_PT
dc.publisherHindawi Publishing Corporationpt_PT
dc.subjectAryldialkylphosphatasept_PT
dc.subjectBiomarkerspt_PT
dc.subjectCardiovascular Diseasespt_PT
dc.subjectCholesterol, HDLpt_PT
dc.subjectCholesterol, LDLpt_PT
dc.subjectPortugalpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTriglyceridespt_PT
dc.subjectDiagnostic Techniques, Cardiovascularpt_PT
dc.subjectAdiponectinpt_PT
dc.subjectUric Acidpt_PT
dc.titleEmergent Biomarkers of Residual Cardiovascular Risk in Patients with Low HDL-c and/or High Triglycerides and Average LDL-c Concentrations: Focus on HDL Subpopulations, Oxidized LDL, Adiponectin, and Uric Acidpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific World Journalpt_PT
oaire.citation.volume2013pt_PT
person.familyNamePalavra
person.familyNameMarado
person.familyNameTeixeira-Lemos
person.familyNameMendonca
person.familyNameFernandes Reis
person.givenNameFilipe
person.givenNameDaniela
person.givenNameEdite
person.givenNameMaria Isabel
person.givenNameFlávio Nelson
person.identifier1395515
person.identifier.ciencia-idC91F-BF0C-757A
person.identifier.ciencia-idF71E-A443-C8CB
person.identifier.ciencia-id1C1D-1326-C311
person.identifier.orcid0000-0002-2165-130X
person.identifier.orcid0000-0003-0932-1081
person.identifier.orcid0000-0002-6346-8319
person.identifier.orcid0000-0001-5450-5213
person.identifier.orcid0000-0003-3401-9554
person.identifier.scopus-author-id36626082400
person.identifier.scopus-author-id22836614300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication49fcacf9-dbf8-43cd-af92-c64a6d8749c6
relation.isAuthorOfPublication1508938f-96da-4312-a198-b8dbc456ad53
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