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Epidemiological and Clinical Aspects of Cutaneous and Mucosal Leishmaniases in Portugal: Retrospective Analysis of Cases Diagnosed in Public Hospitals and Reported in the Literature between 2010 and 2020

2024Journal article Open access
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dc.contributor.authorRocha, R
dc.contributor.authorConceição, C
dc.contributor.authorGonçalves, L
dc.contributor.authorCarvalho, AC
dc.contributor.authorMaia, A
dc.contributor.authorMartins, A
dc.contributor.authorCarujo, A
dc.contributor.authorMaio, A
dc.contributor.authorForra, C
dc.contributor.authorMelita, C
dc.contributor.authorCouto, D
dc.contributor.authorFernandes, D
dc.contributor.authorPereira, D
dc.contributor.authorLeal, E
dc.contributor.authorSarmento, H
dc.contributor.authorSousa, I
dc.contributor.authorGonçalves, JP
dc.contributor.authorMarinho, J
dc.contributor.authorVasconcelos, J
dc.contributor.authorCunha, J
dc.contributor.authorRodrigues, J
dc.contributor.authorSilva, JM
dc.contributor.authorCaley, L
dc.contributor.authorMalheiro, L
dc.contributor.authorSantos, L
dc.contributor.authorGarcia, M
dc.contributor.authorCunha, M
dc.contributor.authorLima, M
dc.contributor.authorAndrade, MM
dc.contributor.authorMarques, M
dc.contributor.authorAlpalhão, M
dc.contributor.authorSilva, M
dc.contributor.authorFerraz, R
dc.contributor.authorSoares, R
dc.contributor.authorFernandes, S
dc.contributor.authorLlobet, S
dc.contributor.authorCruz, S
dc.contributor.authorGuimarães, T
dc.contributor.authorBranco, T
dc.contributor.authorRobalo-Nunes, T
dc.contributor.authorAlmeida, V
dc.contributor.authorMaia, C
dc.date.accessioned2024-05-30T21:57:49Z
dc.date.available2024-05-30T21:57:49Z
dc.date.issued2024
dc.description.abstractLeishmania infantum, a zoonotic vector-born parasite, is endemic in the Mediterranean region, presenting mostly as visceral (VL), but also as cutaneous (CL) and mucosal leishmaniasis (ML). This study aimed to describe the epidemiological and clinical aspects of the CL and ML cases diagnosed in mainland Portugal between 2010 and 2020. Collaboration was requested from every hospital of the Portuguese National Health System. Cases were screened through a search of diagnostic discharge codes or positive laboratory results for Leishmania infection. Simultaneously, a comprehensive literature search was performed. Descriptive statistics and hypothesis testing were performed using IBM® SPSS® Statistics. A total of 43 CL and 7 ML cases were identified, with a predominance of autochthonous cases (86%). In CL, immunosuppressed individuals constituted a significant proportion of patients (48%), and in this group, disseminated CL (22%) and simultaneous VL (54%) were common. In autochthonous cases, lesions, mostly papules/nodules (62%), were frequently observed on the head (48%). The approach to treatment was very heterogeneous. ML cases were all autochthonous, were diagnosed primarily in older immunosuppressed individuals, and were generally treated with liposomal amphotericin B. The findings suggest a need for enhanced surveillance and reporting, clinical awareness, and diagnostic capacity of these forms of leishmaniasis to mitigate underdiagnosis and improve patient outcomes. A holistic One Health approach is advocated to address the multifaceted challenges posed by leishmaniases in Portugal and beyond.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMicroorganisms . 2024 Apr 18;12(4):819.pt_PT
dc.identifier.doi10.3390/microorganisms12040819pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/50965
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectLeishmaniose Cutâneapt_PT
dc.subjectLeishmaniasis, Cutaneouspt_PT
dc.titleEpidemiological and Clinical Aspects of Cutaneous and Mucosal Leishmaniases in Portugal: Retrospective Analysis of Cases Diagnosed in Public Hospitals and Reported in the Literature between 2010 and 2020pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage819pt_PT
oaire.citation.titleMicroorganismspt_PT
oaire.citation.volume12pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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