Publication
Prognostic value of hyperlactatemia in infected patients admitted to intensive care units: a multicenter study
| dc.contributor.author | Silva, Catarina Mendes | |
| dc.contributor.author | Baptista, João Pedro | |
| dc.contributor.author | Mergulhão, Paulo | |
| dc.contributor.author | Froes, Filipe | |
| dc.contributor.author | Gonçalves-Pereira, João | |
| dc.contributor.author | Pereira, José Manuel | |
| dc.contributor.author | Dias, Claudia Camila | |
| dc.contributor.author | Paiva, José Artur | |
| dc.date.accessioned | 2023-05-28T10:19:55Z | |
| dc.date.available | 2023-05-28T10:19:55Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Objective: To evaluate the influence of patient characteristics on hyperlactatemia in an infected population admitted to intensive care units and the influence of hyperlactatemia severity on hospital mortality. Methods: A post hoc analysis of hyperlactatemia in the INFAUCI study, a national prospective, observational, multicenter study, was conducted in 14 Portuguese intensive care units. Infected patients admitted to intensive care units with a lactate measurement in the first 12 hours of admission were selected. Sepsis was identified according to the Sepsis-2 definition accepted at the time of data collection. The severity of hyperlactatemia was classified as mild (2 - 3.9mmol/L), moderate (4.0 - 9.9mmol/L) or severe (> 10mmol/L). Results: In a total of 1,640 patients infected on admission, hyperlactatemia occurred in 934 patients (57%), classified as mild, moderate and severe in 57.0%, 34.4% and 8.7% of patients, respectively. The presence of hyperlactatemia and a higher degree of hyperlactatemia were both associated with a higher Simplified Acute Physiology Score II, a higher Charlson Comorbidity Index and the presence of septic shock. The lactate Receiver Operating Characteristic curve for hospital mortality had an area under the curve of 0.64 (95%CI 0.61 - 0.72), which increased to 0.71 (95%CI 0.68 - 0.74) when combined with Sequential Organ Failure Assessment score. In-hospital mortality with other covariates adjusted by Simplified Acute Physiology Score II was associated with moderate and severe hyperlactatemia, with odds ratio of 1.95 (95%CI 1.4 - 2.7; p < 0.001) and 4.54 (95%CI 2.4 - 8.5; p < 0.001), respectively. Conclusion: Blood lactate levels correlate independently with in-hospital mortality for moderate and severe degrees of hyperlactatemia. | pt_PT |
| dc.description.sponsorship | This work was supported by an unrestricted grant from Grupo de Infeção e Sépsis (GIS), Porto, Portugal. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.5935/0103-507X.20220010-en | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.26/44914 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.subject | Hyperlactatemia | pt_PT |
| dc.subject | Infections | pt_PT |
| dc.subject | Lactate | pt_PT |
| dc.subject | Hospital mortality | pt_PT |
| dc.subject | Prognosis | pt_PT |
| dc.subject | Intensive care units | pt_PT |
| dc.title | Prognostic value of hyperlactatemia in infected patients admitted to intensive care units: a multicenter study | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 162 | pt_PT |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 154 | pt_PT |
| oaire.citation.title | Revista Brasileira de Terapia Intensiva | pt_PT |
| oaire.citation.volume | 34 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |