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Publication
Utilização dos péptidos antimicrobianos em medicina dentária
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Advisor(s)
Abstract(s)
Atualmente, a resistência bacteriana é considerada um importante problema de saúde pública, sendo assim imperativo a descoberta de novos medicamentos que consigam fazer face a estes microrganismos. Os péptidos antimicrobianos (AMPs) fazem parte do sistema imunitário inato, e caracterizam-se por possuir um largo espectro de ação
contra bactérias, fungos, e vírus, sendo uma alternativa promissora aos antibióticos
clássicos. Adicionalmente, o desenvolvimento de resistência por parte das bactérias a
estes péptidos é significativamente inferior à dos antibióticos convencionais.
Em medicina dentária os AMPs têm demonstrado resultados promissores em áreas como a periodontologia, implantologia, endodontia, e principalmente em áreas de
prevenção da formação de biofilmes, e de processos cariogénicos. Especificamente, β-
defensinas, histatinas, hBD, HNP, e LL37, têm uma atividade antibacteriana versátil
contra bactérias orais, tendo já respostas positivas e prometedoras a problemas até agora difíceis.
Esta monografia tem como objetivo de mostrar o potencial dos AMPs nestas áreas, e em uso clínico, bem como rever alguns dos seus mecanismos de ação e resistência.
Currently, bacterial resistance is considered an important public health problem, so it is imperative to discover new drugs that can cope with these microorganisms. Antimicrobial peptides (AMPs) are part of the innate immune system, and are characterized by a broad spectrum of action against bacteria, fungi, and viruses, and are a promising alternative to classical antibiotics. In addition, the development of resistance by the bacteria to these peptides is significantly lower than that of conventional antibiotics. In dental medicine, AMPs have shown promising results in areas such as periodontics, implantology, endodontics, and especially in areas of biofilm formation prevention and cariogenic processes. Specifically, β-defensins, histatins, hBD, HNP, and LL37, have versatile antibacterial activity against oral bacteria, already having positive and promising responses to hitherto difficult problems. This monograph aims to show the potential of MPAs in these areas, and in clinical use, as well as to review some of their mechanisms of action and resistance.
Currently, bacterial resistance is considered an important public health problem, so it is imperative to discover new drugs that can cope with these microorganisms. Antimicrobial peptides (AMPs) are part of the innate immune system, and are characterized by a broad spectrum of action against bacteria, fungi, and viruses, and are a promising alternative to classical antibiotics. In addition, the development of resistance by the bacteria to these peptides is significantly lower than that of conventional antibiotics. In dental medicine, AMPs have shown promising results in areas such as periodontics, implantology, endodontics, and especially in areas of biofilm formation prevention and cariogenic processes. Specifically, β-defensins, histatins, hBD, HNP, and LL37, have versatile antibacterial activity against oral bacteria, already having positive and promising responses to hitherto difficult problems. This monograph aims to show the potential of MPAs in these areas, and in clinical use, as well as to review some of their mechanisms of action and resistance.
Description
Dissertação para obtenção do grau de Mestre no Instituto Universitário Egas Moniz
Keywords
Péptidos antimicrobianos Medicina dentária Cárie Peri-implantite Endodontia