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Treatment patterns and preferences of people living with HIV starting or switching antiretroviral therapy: Real-world evidence from Portugal

2024Journal article Open access
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dc.contributor.authorPedro, L
dc.contributor.authorZagalo, A
dc.contributor.authorTavares, R
dc.contributor.authorPacheco, P
dc.contributor.authorOliveira, J
dc.contributor.authorVaz Pinto, I
dc.contributor.authorSerrão, R
dc.contributor.authorTavares, S
dc.contributor.authorBrito, P
dc.contributor.authorMaltez, F
dc.contributor.authorNeves, I
dc.contributor.authorCarvalho, A
dc.contributor.authorTeófilo, E
dc.contributor.authorAlmeida, J
dc.contributor.authorLains, I
dc.date.accessioned2024-07-26T20:58:08Z
dc.date.available2024-07-26T20:58:08Z
dc.date.issued2024
dc.description.abstractBackground: There is a lack of up-to-date real-life evidence on antiretroviral therapy (ART) strategies among people living with HIV (PLWH) in Portugal. This study aimed to describe the treatment strategy used in PLWH either initiating or switching ART. Methods: Non-interventional, cross-sectional, multicenter study carried out between December 2019 and October 2021 in Portugal. Results: A total of 237 PLWH were included in this study, 171 of whom were ART-experienced and 66 were ART-naïve. The study showed that triple regimens were the most common ART strategy and integrase strand transfer inhibitors-based therapy was the most frequently used therapeutic class in both ART-naïve and ART-experienced PLWH. Nevertheless, about a third of PLWH who started a triple regimen transitioned to a dual regimen. Patient-reported outcomes revealed high HIV literacy and similar ART preferences in both groups. Conclusions: This real-world study showed that triple regimens were the most widely used ART strategy, even after the European AIDS Clinical Society guidelines introduced the recommendation of a dual regimen for naïve patients. The cohorts of this study presented a high level of HIV literacy at the time of inclusion. Our findings highlighted that taking pills only once a day is considered a very important feature for most patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt J STD AIDS . 2024 Jul 25:9564624241263122.pt_PT
dc.identifier.doi10.1177/09564624241263122pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/51392
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAntirretroviraispt_PT
dc.subjectInfecções por VIHpt_PT
dc.subjectAnti-Retroviral Agentspt_PT
dc.subjectHIV Infectionspt_PT
dc.titleTreatment patterns and preferences of people living with HIV starting or switching antiretroviral therapy: Real-world evidence from Portugalpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleInternational Journal of STD & AIDSpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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