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Mastocitoma cutâneo canino
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Abstract(s)
O mastocitoma (MTC) é a neoplasia cutânea mais comum em cães. Apresenta uma clara predisposição
racial descrita em diferentes estudos, e um prognóstico muito variável.
Este estudo teve como objetivos realizar a caracterização de uma população de cães com mastocitoma
cutâneo e determinar os fatores de risco e fatores de prognóstico associados.
No presente estudo foram avaliados, de forma retrospetiva, 48 casos clínicos de mastocitomas cutâneos
caninos diagnosticados entre Julho de 2014 e Dezembro de 2018 no Centro Hospitalar Veterinário, do
Porto, Portugal. Foram analisados os seguintes dados como fatores de risco e/ou prognóstico: idade,
raça, género, localização, classificação histopatológica de Patnaik e/ou Kiupel e tempo de sobrevida.
A mediana de idades dos animais avaliados foi de 11.0 anos (mínimo 3.0 anos; máximo 18.6 anos),
sendo que 17 eram machos e 31 fêmeas. A maioria dos animais analisados não tinha raça definida (n=15;
31%; p=0.14). Considerando os animais de raça pura, as mais representadas foram o Labrador Retriever
(n=10; 21%; p<0.005), Boxer (n=6; 13%; p<0.005), Golden Retriever (n=5; 10%; p<0.05) e Jack Russel
(n=3; 6%; p<0.005). As fêmeas apresentaram-se neste estudo como o grupo mais afetado por esta
neoplasia (p=0.045). A localização mais frequente dos mastocitomas cutâneos foi nos membros (n=16;
33%). Na análise do tempo de sobrevida o grau de Patnaik (p=0.01) foi identificado como fator de
prognóstico, sendo que a raça (p=0.8), o sexo (p=0.67), o grau de Kiupel (p=0.21) e a localização (p=0.48)
não apresentaram relação estatisticamente significativa com a sobrevida dos animais.
Os resultados obtidos demonstraram a existência de uma predisposição de raça e género nos MTC
cutâneos caninos. A classificação histopatológica dos MTC cutâneos caninos de acordo com a graduação
de Patnaik apresentou valor prognóstico.
Mast cell tumors (MCT) are the most common cutaneous neoplasms in dogs. They present a strong breed predisposition described in different studies, and a variable prognosis. The main objectives of this study were to characterize a population of dogs diagnosed with cutaneous mast cell tumours, and to evaluate risk and prognostic factors. Forty-eight dogs with cutaneous mast cell tumors that were presented to the Centro Veterinário Hospitalar, Porto, Portugal, between July 2014 and December 2018 were retrospectively studied. Age, breed, gender, location, Patnaik and / or Kiupel histopathological classification and survival time were evaluated as risk and/or prognostic factors. The median age of the animals enrolled in the study was 11.0 years (minimum 3.0; máximum 18.6 years), with 17 males and 31 females. Cross-breed dogs were the most represented (n=15; 31%, p=0.14). Considering the pure-breed animals, the most frequent were the Labrador Retriever (n=10; 21%, p=0.005), Boxer (n=6; 13%, p<0.005), Golden Retriever (n=5; 10%; p<0.05) and Jack Russel Terriers (n=3, 6%, p <0.005). In this study, a gender predisposition was observed, with females being significantly more affected than males (p=0.045). Cutaneous mast cell tumors were most frequent in the limbs (n=16; 33%). No significant influence of breed (p=0.8), gender (p=0.67), Kiupel histopathological classification (p=0.21) and location (p=0.48) was detected on survival times of the animals evaluated. The results of this study demonstrated the existence of a predisposition of gender and breed in canine cutaneous MCT. The histopathological classification of canine cutaneous MCT according to Patnaik's graduation showed a prognostic value.
Mast cell tumors (MCT) are the most common cutaneous neoplasms in dogs. They present a strong breed predisposition described in different studies, and a variable prognosis. The main objectives of this study were to characterize a population of dogs diagnosed with cutaneous mast cell tumours, and to evaluate risk and prognostic factors. Forty-eight dogs with cutaneous mast cell tumors that were presented to the Centro Veterinário Hospitalar, Porto, Portugal, between July 2014 and December 2018 were retrospectively studied. Age, breed, gender, location, Patnaik and / or Kiupel histopathological classification and survival time were evaluated as risk and/or prognostic factors. The median age of the animals enrolled in the study was 11.0 years (minimum 3.0; máximum 18.6 years), with 17 males and 31 females. Cross-breed dogs were the most represented (n=15; 31%, p=0.14). Considering the pure-breed animals, the most frequent were the Labrador Retriever (n=10; 21%, p=0.005), Boxer (n=6; 13%, p<0.005), Golden Retriever (n=5; 10%; p<0.05) and Jack Russel Terriers (n=3, 6%, p <0.005). In this study, a gender predisposition was observed, with females being significantly more affected than males (p=0.045). Cutaneous mast cell tumors were most frequent in the limbs (n=16; 33%). No significant influence of breed (p=0.8), gender (p=0.67), Kiupel histopathological classification (p=0.21) and location (p=0.48) was detected on survival times of the animals evaluated. The results of this study demonstrated the existence of a predisposition of gender and breed in canine cutaneous MCT. The histopathological classification of canine cutaneous MCT according to Patnaik's graduation showed a prognostic value.
Description
Keywords
Cão Tumor cutâneo Epidemiologia Mastocitoma Cutaneous Dog Epidemiology Mast cell tumor