Repository logo
 
Publication

Substantia nigra neuromelanin as an imaging biomarker of disease progression in Parkinson’s Disease

2017-08Journal article Open access
Simple item page
dc.contributor.authorFabbri, Margherita
dc.contributor.authorReimão, Sofia
dc.contributor.authorCarvalho, Miguel
dc.contributor.authorNunes, Rita G.
dc.contributor.authorAbreu, Daisy
dc.contributor.authorGuedes, Leonor Correia
dc.contributor.authorBouça, Raquel
dc.contributor.authorLobo, Patrícia P.
dc.contributor.authorGodinho, Catarina
dc.contributor.authorCoelho, Miguel
dc.contributor.authorGonçalves, Nilza C.
dc.contributor.authorRosa, Mario Miguel
dc.contributor.authorAntonini, Angelo
dc.contributor.authorFerreira, Joaquim J.
dc.date.accessioned2019-10-10T13:46:11Z
dc.date.available2019-10-10T13:46:11Z
dc.date.issued2017-08
dc.description.abstract"BACKGROUND: A specific T1-weighted magnetic resonance imaging (MRI) sequence has been shown to detect substantia nigra (SN) neuromelanin (NM) signal changes that accurately discriminate Parkinson's disease (PD) patients from controls, even in early disease stages. However, it is unclear what happens to these SN changes in later disease stages and if they can be a marker of disease progression. OBJECTIVE: to investigate the pattern of SN-NM area loss and contrast ratio (CR) intensity changes in late-stage PD (LSPD) compared to earlier disease stages. METHODS: A comparative cross-sectional study was performed, analyzing SN-NM MRI signal in LSPD (Schwab and England Activities of Daily Living Scale score <50 or Hoehn Yahr Stage [HY] >3), comparing this group with de novo, 2-5 year PD and controls. SN-NM signal area and CR values for the internal and lateral SN regions were obtained with semi-automated methods. RESULTS: 13 LSPD, 12 de novo patients with PD, 10 PD patients with a 2-5 year disease duration, and 10 controls were included. NM signal area was significantly decreased in LSPD compared to de novo PD (P-value = 0.005; sensitivity: 75%; specificity 92% and AUC: 0.86). In the lateral SN region, a decrease in the CR was detected in all PD groups compared to controls; despite not reaching statistical significance, a slight increment was observed comparing LSPD to 2-5 year PD. NM signal area significantly correlated with HY (R = -0.37; P < 0.05) and Movement disorder Society Unified Parkinson's Disease Rating Scale part II (MDS-UPDRS) (R = -0.4; P < 0.05) while a weak correlation was found with MDS-UPDRS part III (R = -0.26; P: 0.1). CONCLUSION: SN area evaluated by NM-sensitive MRI may be a promising biomarker of nigral degeneration and disease progression in PD patients."pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Parkinsons Dis. 2017;7(3):491-501. doi: 10.3233/JPD-171135pt_PT
dc.identifier.doi10.3233/JPD-171135pt_PT
dc.identifier.issn1877-7171
dc.identifier.urihttp://hdl.handle.net/10400.26/29906
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOS Presspt_PT
dc.relation.publisherversionThe final publication is available at IOS Press through http://dx.doi.org/10.3233/JPD-171135pt_PT
dc.subjectNeuromelaninpt_PT
dc.subjectParkinson’s diseasept_PT
dc.subjectBiomarkerpt_PT
dc.subjectDisease progressionpt_PT
dc.subjectLate-stagept_PT
dc.titleSubstantia nigra neuromelanin as an imaging biomarker of disease progression in Parkinson’s Diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage501pt_PT
oaire.citation.startPage491pt_PT
oaire.citation.titleJournal of Parkinson's Diseasept_PT
oaire.citation.volume7(3)pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Artigo_CGodinho_2017_03_accepted_manuscript.pdf
Size:
728.47 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.85 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

EM - Artigos Científicos