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Publication
Rhodococcus Equi Em Poldros: Estratégias De Prevenção, Abordagens Terapêuticas E Gestão Das Resistências Antibacterianas
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Advisor(s)
Abstract(s)
A infeção por Rhodococcus equi (R. equi) em poldros é uma preocupação significativa na indústria da reprodução equina, causando uma alta taxa de mortalidade e morbidade. Além disso, pode prejudicar a futura carreira desportiva do animal. A rodococose manifesta-se principalmente sob a forma de pneumonia, mas os poldros afetados também podem apresentar sinais extrapulmonares, como linfadenite ou polissinovite. Durante anos, era comum fazer um rastreio dos poldros usando a ecografia e tratar os animais que apresentavam formas subclínicas da doença. O tratamento utilizado durante décadas consistia em uma combinação de macrolídeos e rifampicina. No entanto, recentemente, muitos estudos relatam uma crescente emergência de resistência antimicrobiana, tornando o tratamento de alguns animais mais desafiador. Isso ressalta a importância da vigilância contínua e do uso prudente de antibióticos para minimizar o desenvolvimento de resistências. Quando o diagnóstico é confirmado, o tratamento imediato do animal é essencial para maximizar suas hipóteses de recuperação. Isso pode envolver uma combinação de antibióticos, além de terapia de suporte para controlar os sintomas respiratórios e extrapulmonares. A prevenção desempenha um papel crucial na redução da incidência dessa infeção, envolvendo estratégias como administração de soro hiperimune, vacinação quando disponível, maneio do ambiente e identificação precoce dos poldros em risco. Muitos desafios persistem na abordagem dessa patologia, incluindo a pesquisa de novos tratamentos, a gestão adequada da resistência emergente e a busca por uma vacina eficaz contra R. equi.
Rhodococcus equi (R. equi) in foals is a significant concern in the equine industry, causing high rates of 59 mortality and morbidity. Additionally, it can impair the future sporting career of the animal. 60 Rhodococcosis primarily manifests in the form of pneumonia, but affected foals may also show 61 extrapulmonary signs such as lymphadenitis or polysynovitis. For years, it has been common practice 62 to screen foals using ultrasonography and treat animals with subclinical forms of the disease. The 63 treatment regimen used for decades consisted of a combination of macrolides and 64 rifampicin.However, recently, many studies report a growing emergence of antimicrobial resistance, 65 making the treatment of some animals more challenging. This underscores the importance of 66 continuous surveillance and prudent use of antibiotics to minimize the development of resistance. 67 When the diagnosis is confirmed, immediate treatment of the animal is essential to maximize its 68 chances of recovery. This may involve a combination of antibiotics, along with supportive therapy to 69 control both respiratory and extrapulmonary symptoms. Prevention plays a crucial role in reducing the 70 incidence of this infection, involving strategies such as hyperimmune serum administration, 71 vaccination when available, environmental management, and early identification of foals at risk. Many 72 challenges persist in addressing this pathology, including researching new treatments, managing the 73 emerging resistance appropriately, and seeking an effective vaccine against R. equi.
Rhodococcus equi (R. equi) in foals is a significant concern in the equine industry, causing high rates of 59 mortality and morbidity. Additionally, it can impair the future sporting career of the animal. 60 Rhodococcosis primarily manifests in the form of pneumonia, but affected foals may also show 61 extrapulmonary signs such as lymphadenitis or polysynovitis. For years, it has been common practice 62 to screen foals using ultrasonography and treat animals with subclinical forms of the disease. The 63 treatment regimen used for decades consisted of a combination of macrolides and 64 rifampicin.However, recently, many studies report a growing emergence of antimicrobial resistance, 65 making the treatment of some animals more challenging. This underscores the importance of 66 continuous surveillance and prudent use of antibiotics to minimize the development of resistance. 67 When the diagnosis is confirmed, immediate treatment of the animal is essential to maximize its 68 chances of recovery. This may involve a combination of antibiotics, along with supportive therapy to 69 control both respiratory and extrapulmonary symptoms. Prevention plays a crucial role in reducing the 70 incidence of this infection, involving strategies such as hyperimmune serum administration, 71 vaccination when available, environmental management, and early identification of foals at risk. Many 72 challenges persist in addressing this pathology, including researching new treatments, managing the 73 emerging resistance appropriately, and seeking an effective vaccine against R. equi.
Description
Keywords
Macrolideos Poldros Resistência Rhodococose Equi Rifampicina Macrolides Foals Resistance Rhodococcus Equi Rifampicin