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Lymph node remodelling underlies the attenuated form of HIV/AIDS in people with HIV-2

2026-06Contributo em revista Acesso aberto
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datacite.subject.fosCiências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFernandes, Susana M.
dc.contributor.authorFarias, Guilherme B.
dc.contributor.authorPires, Ana R.
dc.contributor.authorSantos, Diana F.
dc.contributor.authorAntão, Ana Vieira
dc.contributor.authorPires, André
dc.contributor.authorMoura, Rita
dc.contributor.authorGodinho-Santos, Ana
dc.contributor.authorMarques, Rita T.
dc.contributor.authorGomes, André M. C.
dc.contributor.authorFerreira, Cristina
dc.contributor.authorNunes-Cabaço, Helena
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPoças, José
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorBadura, Robert
dc.contributor.authorSousa, Ana E.
dc.date.accessioned2026-06-15T10:46:41Z
dc.date.available2026-06-15T10:46:41Z
dc.date.issued2026-06
dc.description.abstractHIV-2 infection is associated with low-to-undetectable plasma viral load, broad and sustained specific antibody and T cell responses, and a slow course of CD4 T cell decline, even in the absence of antiretroviral therapy (ART). Here, we investigated the secondary lymphoid organs of people with HIV-2 (PWH2) as compared to people with HIV-1 (PWH1) and seronegative subjects. We found active HIV-2 replication and major disruption of lymph node architecture in PWH2, also attested by the alterations that we demonstrated in the blood counterparts of follicular T and B cells. These findings were corroborated by in vitro infection assays using tonsil organ cultures and HIV-2 or HIV-1 primary isolates with distinct co-receptor usage, CCR5 or CXCR4, which showed significant HIV-2 cytopathogenicity associated with post-transcriptional control of HIV-2 replication, revealed by high titres of cell-associated viral DNA and mRNA transcripts but reduced HIV-2 protein production. Overall, our findings support a major impact of HIV-2 on secondary lymphoid tissue organisation throughout the disease course, stressing the relevance of this neglected infection to understand host-pathogen equilibrium in retroviral zoonoses and to identify strategies towards a functional HIV cure.eng
dc.identifier.citationSusana M. Fernandes, Guilherme B. Farias, Ana R. Pires, Diana F. Santos, Ana Vieira Antão, André Pires, Rita Moura, Ana Godinho-Santos, Rita T. Marques, André MC Gomes, Cristina Ferreira, Helena Nunes-Cabaço, Perpétua Gomes, José Poças, Carlos Vasconcelos, Robert Badura, Ana E. Sousa, Lymph node remodelling underlies the attenuated form of HIV/AIDS in people with HIV-2, Journal of Infection, Volume 92, Issue 6, 2026, 106760, https://doi.org/10.1016/j.jinf.2026.106760
dc.identifier.doi10.1016/j.jinf.2026.106760
dc.identifier.issn0163-4453
dc.identifier.urihttp://hdl.handle.net/10400.26/63579
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relation.hasversionhttps://doi.org/10.1016/j.jinf.2026.106760
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectHIV
dc.subjectHIV-2
dc.subjectLymph nodes
dc.subjectGerminal centre
dc.subjectT lymphocytes
dc.subjectVirus replication
dc.titleLymph node remodelling underlies the attenuated form of HIV/AIDS in people with HIV-2eng
dc.typecontribution to journal
dspace.entity.typePublication
oaire.citation.issue6
oaire.citation.startPage106760
oaire.citation.titleJournal of Infection
oaire.citation.volume92
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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