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Determinants of HIV late presentation among men who have sex with men in Portugal (2014–2019): who’s being left behind?

2024Journal article Open access
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dc.contributor.authorAbrantes, Ricardo
dc.contributor.authorPimentel, Victor
dc.contributor.authorMiranda, Mafalda N. S.
dc.contributor.authorSilva, Ana Rita
dc.contributor.authorDiniz, António
dc.contributor.authorAscenção, Bianca
dc.contributor.authorPiñeiro, Carmela
dc.contributor.authorKoch, Carmo
dc.contributor.authorRodrigues, Catarina
dc.contributor.authorCaldas, Cátia
dc.contributor.authorMorais, Célia
dc.contributor.authorFaria, Domitília
dc.contributor.authorGomes da Silva, Elisabete
dc.contributor.authorTeófilo, Eugénio
dc.contributor.authorMonteiro, Fátima
dc.contributor.authorRoxo, Fausto
dc.contributor.authorMaltez, Fernando
dc.contributor.authorRodrigues, Fernando
dc.contributor.authorGaião, Guilhermina
dc.contributor.authorRamos, Helena
dc.contributor.authorCosta, Inês
dc.contributor.authorGermano, Isabel
dc.contributor.authorSimões, Joana
dc.contributor.authorOliveira, Joaquim
dc.contributor.authorFerreira, José
dc.contributor.authorPoças, José
dc.contributor.authorSaraiva da Cunha, José
dc.contributor.authorSoares, Jorge
dc.contributor.authorFernandes, Sandra
dc.contributor.authorMansinho, Kamal
dc.contributor.authorPedro, Liliana
dc.contributor.authorAleixo, Maria João
dc.contributor.authorGonçalves, Maria João
dc.contributor.authorManata, Maria José
dc.contributor.authorMouro, Margarida
dc.contributor.authorSerrado, Margarida
dc.contributor.authorCaixeiro, Micaela
dc.contributor.authorMarques, Nuno
dc.contributor.authorCosta, Olga
dc.contributor.authorPacheco, Patrícia
dc.contributor.authorProença, Paula
dc.contributor.authorRodrigues, Paulo
dc.contributor.authorPinho, Raquel
dc.contributor.authorTavares, Raquel
dc.contributor.authorCorreia de Abreu, Ricardo
dc.contributor.authorCôrte-Real, Rita
dc.contributor.authorSerrão, Rosário
dc.contributor.authorSarmento e Castro, Rui
dc.contributor.authorNunes, Sofia
dc.contributor.authorFaria, Telo
dc.contributor.authorBaptista, Teresa
dc.contributor.authorSimões, Daniel
dc.contributor.authorMendão, Luís
dc.contributor.authorMartins, M. Rosário O.
dc.contributor.authorGomes, Perpétua
dc.contributor.authorPingarilho, Marta
dc.contributor.authorAbecasis, Ana B.
dc.date.accessioned2024-09-19T11:10:42Z
dc.date.available2024-09-19T11:10:42Z
dc.date.issued2024
dc.description.abstractIntroduction: HIV late presentation (LP) remains excessive in Europe. We aimed to analyze the factors associated with late presentation in the MSM population newly diagnosed with HIV in Portugal between 2014 and 2019. Methods: We included 391 newly HIV-1 diagnosed Men who have Sex with Men (MSM), from the BESTHOPE project, in 17 countrywide Portuguese hospitals. The data included clinical and socio-behavioral questionnaires and the viral genomic sequence obtained in the drug resistance test before starting antiretrovirals (ARVs). HIV-1 subtypes and epidemiological surveillance mutations were determined using different bioinformatics tools. Logistic regression was used to estimate the association between predictor variables and late presentation (LP). Results: The median age was 31 years, 51% had a current income between 501-1,000 euros, 28% were migrants. 21% had never been tested for HIV before diagnosis, with 42.3% of MSM presenting LP. 60% were infected with subtype B strains. In the multivariate regression, increased age at diagnosis, higher income, lower frequency of screening, STI ever diagnosed and higher viral load were associated with LP. Conclusion: Our study suggests that specific subgroups of the MSM population, such older MSM, with higher income and lower HIV testing frequency, are not being targeted by community and clinical screening services. Overall, targeted public health measures should be strengthened toward these subgroups, through strengthened primary care testing, expanded access to PrEP, information and promotion of HIV self-testing and more inclusive and accessible health services.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3389/fpubh.2024.1336845pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/52122
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
dc.relationGlobal Health and Tropical Medicine
dc.relationGlobal Health and Tropical Medicine
dc.relationTranslation and Innovation towards Global Health
dc.relationCharacterization of HIV-1 Drug Resistance to Integrase Inhibitors in Portugal: clinical and economic impact for treatment and drug resistance testing guidelines
dc.relationMinimizing the emergence and dissemination of HIV-1 drug resistance in PALOPs through an evidence-based portable high-throughput sequencing and computational approach.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectHIVpt_PT
dc.subjectLate diagnosispt_PT
dc.subjectMen who have sex with menpt_PT
dc.subjectDrug resistancept_PT
dc.titleDeterminants of HIV late presentation among men who have sex with men in Portugal (2014–2019): who’s being left behind?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleHarmonizing, Integrating and Vitalizing European Research on hiv/Aids
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleGlobal Health and Tropical Medicine
oaire.awardTitleTranslation and Innovation towards Global Health
oaire.awardTitleCharacterization of HIV-1 Drug Resistance to Integrase Inhibitors in Portugal: clinical and economic impact for treatment and drug resistance testing guidelines
oaire.awardTitleMinimizing the emergence and dissemination of HIV-1 drug resistance in PALOPs through an evidence-based portable high-throughput sequencing and computational approach.
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/249697/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04413%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04413%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0117%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F7066%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-INF%2F31990%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FSAU-PUB%2F4018%2F2021/PT
oaire.citation.titleFrontiers in Public Healthpt_PT
oaire.citation.volume12pt_PT
oaire.fundingStreamFP7
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamConcurso de Projetos IC&DT em Todos os Domínios Científicos
person.familyNameSimões
person.familyNamePenim Mendão
person.givenNameDaniel
person.givenNameLuís Manuel
person.identifierAAW-2241-2021
person.identifier.ciencia-id1818-7825-CF26
person.identifier.ciencia-idAA16-B94D-A1A0
person.identifier.orcid0000-0001-7799-9631
person.identifier.orcid0000-0001-7595-4499
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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