Characterization of multidrug-resistant diabetic foot ulcer enterococci

Semedo-Lemsaddek, Teresa; Mottola, Carla; Alves-Barroco, Cynthia; Cavaco-Silva, Patrícia; Tavares, Luís; Oliveira, Manuela

http://hdl.handle.net/10400.26/18425

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Authors

Semedo-Lemsaddek, Teresa

Mottola, Carla

Alves-Barroco, Cynthia

Cavaco-Silva, Patrícia

Tavares, Luís

Oliveira, Manuela

Abstract(s)

Introduction: Diabetes mellitus is a highly prevalent chronic progressive disease with complications that include diabetic-foot ulcers. Methods: Enterococci isolated from diabetic-foot infections were identified, evaluated by macrorestriction analysis, and screened for virulence traits and antimicrobial resistance. Results: All isolates were considered multidrug-resistant, cytolysin and gelatinase producers, and the majority also demonstrated the ability to produce biofilms. Conclusions: These results indicate the importance of enterococci in diabetic-foot infection development and persistence, especially regarding their biofilm-forming ability and resistance to clinically relevant antibiotics.