Publication
Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion
| dc.contributor.author | Martinelli-Kläy, C. P. | |
| dc.contributor.author | Lombardi, T. | |
| dc.contributor.author | Mendis, B. R. R. N. | |
| dc.contributor.author | Soares, E. G. | |
| dc.contributor.author | Salvado, F. | |
| dc.contributor.author | Courvoisier, D. S. | |
| dc.contributor.author | Maurício, Paulo | |
| dc.date.accessioned | 2019-07-25T13:57:02Z | |
| dc.date.available | 2019-07-25T13:57:02Z | |
| dc.date.issued | 2018-02 | |
| dc.description.abstract | Objective: to investigate the presence of eosinophils in oral intraepithelial neoplasia (OIN) and oral squamous cell carcinoma (OSCC) lesions and its relation to invasion. | pt_PT |
| dc.description.abstract | Subjects and methods: ninety‐nine oral biopsies were selected and subdivided into the following: OIN‐1(16 cases), OIN‐2 (18 cases), OIN‐3 (17 cases), microinvasive OSCC (10 cases), non‐metastatic OSCC (22 cases) and metastatic OSCC (16 cases). The tissue eosinophilia was evaluated histologically in slices stained with haematoxylin and eosin. | pt_PT |
| dc.description.abstract | Results: Eosinophil distribution was associated with diagnosis severity (p < .01). A significant difference was found between OIN‐3 or microinvasive OSCC and non‐metastatic or metastatic OSCC. Stromal invasion threshold was 7 eos/10 high power field (hpf) (96.1% specificity and 62.5% sensitivity). Eosinophils were absent in OIN‐1; in OIN‐2, two cases were positive. In OIN‐3, five cases showed tissue eosinophilia, four of which had ≥3 eos/hpf or ≥7 eos/10 hpf. Three cases were suspected of invasion; two had a previous history of OSCC with elevated eosinophil infiltrate. In microinvasive OSCC, the four positive cases presented ≥3 eos/hpf and ≥7 eos/10 hpf. Although not significantly different, non‐metastatic invasive OSCC had a higher number of cases (68.2%) with ≥22 eos/10 hpf contrasting with 50% in metastatic OSCC. | pt_PT |
| dc.description.abstract | Conclusion: our results suggest that eosinophils can be considered an indicator of invasion in OIN, helping in cases of difficult diagnosis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Martinelli‐Kläy, CP, Lombardi, T, Mendis, BRRN, et al. Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion. Oral Dis. 2018; 24: 103– 108. https://doi.org/10.1111/odi.12789 | pt_PT |
| dc.identifier.doi | 10.1111/odi.12789 | pt_PT |
| dc.identifier.issn | 1601-0825 | |
| dc.identifier.uri | http://hdl.handle.net/10400.26/29349 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | John Wiley and Sons | pt_PT |
| dc.relation.publisherversion | https://doi.org/10.1111/odi.12789 | pt_PT |
| dc.subject | Oral epithelial dysplasia | pt_PT |
| dc.subject | Oral intraepithelial neoplasia | pt_PT |
| dc.subject | Oral squamous cell carcinoma | pt_PT |
| dc.subject | Tissue eosinophilia | pt_PT |
| dc.title | Tissue eosinophilia in oral intraepithelial neoplasia as a probable indicator of invasion | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 108 | pt_PT |
| oaire.citation.startPage | 103 | pt_PT |
| oaire.citation.title | Oral Diseases | pt_PT |
| oaire.citation.volume | 24 | pt_PT |
| rcaap.embargofct | Política de copyright do editor | pt_PT |
| rcaap.rights | closedAccess | pt_PT |
| rcaap.type | article | pt_PT |