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Advisor(s)
Abstract(s)
We report a case of a cerebral venous thrombosis (CVT) in a chronic kidney disease patient with three CVT predisposing conditions. A 53 year-old woman on chronic peritoneal dialysis presented to the emergency
department with acute headache and vertigo. The neurological examination and head CT scan performed at
the emergency department were normal but, three days later, a lateral gait deviation and a horizontal nystagmus were identified. A brain MRI and MRI-venogram confirmed a left lateral sinus thrombosis. Hormonal
replacement therapy (HRT), a positive lupus anticoagulante and a homozygous mutation on the methylenetetrahydrofolate reductase gene, with hyperhomocysteinaemia, were the three well-known prothrombotic conditions identified in this patient. HRT was discontinued, the patient started anticoagulation with warfarin and folic acid supplementation and was discharged, 10 days after admission, complaining of a mild vertigo. After six months of therapy the patient had vertigo improvement and maintained a positive lupus
anticoagulant. The head MRI and MRI-venography showed a thrombus reduction.
Description
Keywords
cerebral venous thrombosis hyperhomocysteinaemia lupus anticoagulant peritoneal dialysis Madeira Island Portugal left lateral sinus thrombosis
Citation
Port J Nephrol Hypert 2008; 22(1): 49-53