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Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy

2020-03Journal article Open access
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dc.contributor.authorPereira, AM
dc.contributor.authorCouto, M
dc.contributor.authorPereira, M
dc.contributor.authorAraújo, L
dc.date.accessioned2020-03-11T22:47:24Z
dc.date.available2020-03-11T22:47:24Z
dc.date.issued2020-03
dc.description.abstractObjectives. To describe clinical manifestations and performed diagnostic workup, focusing drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis, between 01/2014 - 06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and major or equal 1 hour after drug intake. 59 (78%) diagnoses were based on DCTs, all based on multistep protocols with major or equal 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur Ann Allergy Clin Immunol. 2020 Mar;52(2):74-83.pt_PT
dc.identifier.doi10.23822/EurAnnACI.1764-1489.107pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.26/31694
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectDrug Hypersensitivitypt_PT
dc.subjectHypersensitivity, Immediatept_PT
dc.subjectHipersensibilidade a Medicamentospt_PT
dc.subjectHipersensibilidade Imediatapt_PT
dc.titleSkin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage74-83pt_PT
oaire.citation.titleEuropean annals of allergy and clinical immunologypt_PT
oaire.citation.volume52pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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