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Skin tests and challenge-based drug allergy diagnosis: a retrospective study of patients with confirmed drug allergy
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Resumo(s)
Objectives. To describe clinical manifestations and performed diagnostic workup, focusing drug challenge tests (DCT), in patients with drug allergy. Methods. Retrospective study including all patients with skin tests (STs) or DCT-based drug allergy diagnosis, between 01/2014 - 06/2018 in a Portuguese allergy unit. Data were collected from electronic and paper-based clinical records. Results. We had 75 drug allergy diagnoses. Most index reactions were mild and major or equal 1 hour after drug intake. 59 (78%) diagnoses were based on DCTs, all based on multistep protocols with major or equal 3 predicted steps. Only 10% of the DCT were positive during up-dosing; timing and severity of the index reaction predicted DCT interruption during up-dosing. Conclusions. Most drug allergy diagnoses were based on multistep DCT. The identified predictors of DCT interruption during up-dosing can support the development of more personalized DCTs protocols.
Descrição
Palavras-chave
Drug Hypersensitivity Hypersensitivity, Immediate Hipersensibilidade a Medicamentos Hipersensibilidade Imediata
Contexto Educativo
Citação
Eur Ann Allergy Clin Immunol. 2020 Mar;52(2):74-83.